ArticleAntimicrobial agents and chemotherapy2004
Aspergillus fumigatus variant with decreased susceptibility to multiple antifungals.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- EmergingJAC-antimicrobial resistance · 2024Article
- What do We Know about Cryptic Aspergillosis?Microorganisms · 2024Review
- Life-threatening pulmonary coinfection with Mycobacterium tuberculosis and Aspergillus lentulus in a diabetic patient diagnosed by metagenome next-generation sequencing.BMC infectious diseases · 2023Article
- Virulence capacity of differentFrontiers in immunology · 2023Article
- Comparative Genomics Reveals a Single Nucleotide Deletion inFrontiers in fungal biology · 2022Article
- Article
- Genomic and Phenotypic Heterogeneity of Clinical Isolates of the Human PathogensFrontiers in genetics · 2020Article
- Clinical and Microbiological Characterization of Invasive Pulmonary Aspergillosis Caused byFrontiers in microbiology · 2020Article
- Larvicidal, Histopathological, Antibacterial Activity of Indigenous FungusFrontiers in microbiology · 2019Article
- Aspergillus fumigatus-Related Species in Clinical Practice.Frontiers in microbiology · 2016Review
- Update on Antifungal Drug Resistance.Current clinical microbiology reports · 2015Article
- Early invasive pulmonary aspergillosis in a kidney transplant recipient caused by Aspergillus lentulus: first Brazilian report.Mycopathologia · 2015Article
- An alternative host model of a mixed fungal infection by azole susceptible and resistant Aspergillus spp strains.Virulence · 2015Article
- Aspergillus: sex and recombination.Mycopathologia · 2014Review
- Antifungal susceptibility profile of cryptic species of Aspergillus.Mycopathologia · 2014Review
- The cryptic sexual strategies of human fungal pathogens.Nature reviews. Microbiology · 2014Review
- Discrimination of Aspergillus lentulus from Aspergillus fumigatus by Raman spectroscopy and MALDI-TOF MS.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
- Isavuconazole activity against Aspergillus lentulus, Neosartorya udagawae, and Cryptococcus gattii, emerging fungal pathogens with reduced azole susceptibility.Journal of clinical microbiology · 2013Article
- Discovery of a sexual cycle in Aspergillus lentulus, a close relative of A. fumigatus.Eukaryotic cell · 2013Article
- Susceptibility screening of hyphae-forming fungi with a new, easy, and fast inoculum preparation method.Mycopathologia · 2012Article
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5 authors.
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Abstract
Isolates of Aspergillus fumigatus that demonstrate resistance to itraconazole (ITZ) have been described previously; however, the prevalence and clinical significance of ITZ resistance are not completely understood. In this study we assessed the ITZ susceptibilities of 128 A. fumigatus isolates that caused invasive infection in 82 stem cell transplant patients before and after the use of ITZ in our institution (study period, 1991 to 2000). The MICs for 10 isolates obtained from seven patients were high, > or 1 microg/ml. The average ITZ MIC increased after institutional use of the drug began in 1995. The majority of the isolates for which MICs were high (6 of 10) and one isolate for which the MIC was low (0.06 microg/ml) demonstrated an unusual phenotype, appearing as predominantly white colonies. For all seven atypical isolates, voriconazole MICs were high (> or = 2 microg/ml), and minimal effective concentrations of caspofungin were high (> or 4 microg/ml). For two of the seven atypical isolates, amphotericin B MICs were high (> or 2 microg/ml). The isolates appeared white due to slow sporulation; however, after prolonged incubations, the isolates sporulated with no difference in conidial color or conidiophore morphology compared with typical isolates. Randomly amplified polymorphic DNA-PCR patterns of these isolates were distinct compared with those of other A. fumigatus isolates. Sequencing of 18S rRNA genes confirmed that all were A. fumigatus; however, the mitochondrial cytochrome b gene sequences of all the atypical isolates were unique. These data suggest the potential presence of a genetically unique, poorly sporulating variant of A. fumigatus that demonstrates decreased susceptibilities to several antifungals.
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