ArticleVirchows Archiv : an international journal of pathology2004
Metaplastic mammary carcinoma with osteoclast-like giant cells: identical point mutation of p53 gene only identified in both the intraductal and sarcomatous components.
Article in Virchows Archiv : an international journal of pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- The "Forgotten" Subtypes of Breast Carcinoma: A Systematic Review of Selected Histological Variants Not Included or Not Recognized as Distinct Entities in the Current World Health Organization Classification of Breast Tumors.International journal of molecular sciences · 2024Pooled it
- Whole-Exome Sequencing of Metaplastic Breast Carcinoma Indicates Monoclonality with Associated Ductal Carcinoma Component.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017Article
- Undifferentiated Carcinoma With Osteoclastic Giant Cells of the Pancreas: Clinicopathologic Analysis of 38 Cases Highlights a More Protracted Clinical Course Than Currently Appreciated.The American journal of surgical pathology · 2016Article
- Invasive breast carcinomas of no special type with osteoclast-like giant cells frequently have a luminal phenotype.Virchows Archiv : an international journal of pathology · 2014Article
- Infiltrating mammary carcinoma with osteoclast-like giant cells.Hawaii medical journal · 2010Article
- Osteoclast-like giant cell tumor arising in the soft tissue of the breast: report of a case.Surgery today · 2009Article
- Combined small-cell carcinoma of the stomach: p53 and K-ras gene mutational analysis supports a monoclonal origin of three histological components.International journal of experimental pathology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metaplastic mammary carcinoma with osteoclast-like giant cells is a rare neoplasm, and the histogenesis of this tumor remains controversial. A case of metaplastic mammary carcinoma with osteoclast-like giant cells in a 72-year-old woman is reported with p53 mutational analysis. Microscopically, the tumor was composed of a dominant sarcomatous stromal component containing osteoclast-like giant cells and a minor component of intraductal carcinoma. Immunostaining for p53 revealed strong positivity in both intraductal and sarcomatous components, but not in osteoclast-like giant cells. Mutational analysis of the p53 gene disclosed an identical point mutation in both intraductal and sarcomatous components, but not in osteoclast-like giant cells, indicating that both components share the same progenitor cells, and osteoclast-like giant cells represent a reactive infiltrate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.