Evidence map›Paper›PMID 15045472›Full record

ArticleImmunogenetics2004

Nramp1 deletion does not confer susceptibility to Rhodococcus equi infection in mice.

Noah D Cohen, Jessica Harrington, Philippe Gros, Lucero Del Castro, Dianna Meyer, Ronald J Martens

Abstract read
PubMed Publisher
In one paragraph

Article in Immunogenetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Noah D CohenEquine Infectious Disease Laboratory, Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4475, USA. ncohen@cvm.tamu.edu
Jessica Harrington
Philippe Gros
Lucero Del Castro
Dianna Meyer
Ronald J Martens
Mitchell Institute · USMcGill University · CATexas College · US

Funding

NIAID NIH HHS R01 AI135237
6 · The paper itself

Abstract

Rhodococcus equi is an intracellular bacterium that causes pneumonia in immunocompromised people and foals. The Nramp1 gene influences susceptibility to a variety of intracellular bacteria (including mycobacterial species), but not to Mycobacterium tuberculosis. In this study, we demonstrate that mice functionally deleted of the Nramp1 gene were not more susceptible to infection with virulent R. equi (ATCC 33701) than wild-type mice. Susceptibility of mice to infection with the intracellular bacterium R. equi is more similar to that of M. tuberculosis than to other intracellular bacteria, including other mycobacteria.

Indexed as

Actinomycetales InfectionsAnimalsCation Transport ProteinsColony Count, MicrobialGene DeletionHorsesHumansMiceMice, KnockoutNatural Resistance-associated Macrophage Protein 1Rhodococcus equiVirulenceCation Transport ProteinsNatural Resistance-associated Macrophage Protein 1

Identifiers

PMID15045472
OpenAlexW2043731014

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.