ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Spatial Distribution of Calcium Entry Evoked by Single Action Potentials within the Presynaptic Active Zone.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- Monitoring presynaptic calcium dynamics with membrane-impermeant fluorescent indicators in motor nerve endings.Biophysical reviews · 2025Review
- Microphysiological Modeling of the Structure and Function of Neuromuscular Transmitter Release Sites.Frontiers in synaptic neuroscience · 2022Review
- Biomedical Applications of Translational Optical Imaging: From Molecules to Humans.Molecules (Basel, Switzerland) · 2021Review
- Presynaptic mechanisms controlling calcium-triggered transmitter release at the neuromuscular junction.Current opinion in physiology · 2018Article
- Transmitter release is evoked with low probability predominately by calcium flux through single channel openings at the frog neuromuscular junction.Journal of neurophysiology · 2015Article
- Single calcium channel domain gating of synaptic vesicle fusion at fast synapses; analysis by graphic modeling.Channels (Austin, Tex.) · 2015Article
- Estimation of presynaptic calcium currents and endogenous calcium buffers at the frog neuromuscular junction with two different calcium fluorescent dyes.Frontiers in synaptic neuroscience · 2014Article
- Synaptic vesicle tethering and the CaV2.2 distal C-terminal.Frontiers in cellular neuroscience · 2014Article
- Organization and function of transmitter release sites at the neuromuscular junction.The Journal of physiology · 2013Review
- Evaluation of a novel calcium channel agonist for therapeutic potential in Lambert-Eaton myasthenic syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- An excess-calcium-binding-site model predicts neurotransmitter release at the neuromuscular junction.Biophysical journal · 2013Article
- Optogenetic probing and manipulation of the calyx-type presynaptic terminal in the embryonic chick ciliary ganglion.PloS one · 2013Article
- Are unreliable release mechanisms conserved from NMJ to CNS?Trends in neurosciences · 2013Review
- Deletion of the presynaptic scaffold CAST reduces active zone size in rod photoreceptors and impairs visual processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Molecular mechanism of active zone organization at vertebrate neuromuscular junctions.Molecular neurobiology · 2012Review
- Active zone density is conserved during synaptic growth but impaired in aged mice.The Journal of comparative neurology · 2012Article
- Single-pixel optical fluctuation analysis of calcium channel function in active zones of motor nerve terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Frequency-dependent modes of synaptic vesicle endocytosis and exocytosis at adult mouse neuromuscular junctions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- N-type Ca2+ channels carry the largest current: implications for nanodomains and transmitter release.Nature neuroscience · 2010Article
- (R)-roscovitine prolongs the mean open time of unitary N-type calcium channel currents.Neuroscience · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The nature of presynaptic calcium (Ca(2+)) signals that initiate neurotransmitter release makes these signals difficult to study, in part because of the small size of specialized active zones within most nerve terminals. Using the frog motor nerve terminal, which contains especially large active zones, we show that increases in intracellular Ca(2+) concentration within 1 msec of action potential invasion are attributable to Ca(2+) entry through N-type Ca(2+) channels and are not uniformly distributed throughout active zone regions. Furthermore, changes in the location and magnitude of Ca(2+) signals recorded before and after experimental manipulations (omega-conotoxin GVIA, diaminopyridine, and lowered extracellular Ca(2+)) support the hypothesis that there is a remarkably low probability of a single Ca(2+) channel opening within an active zone after an action potential. The trial-to-trial variability observed in the spatial distribution of presynaptic Ca(2+) entry also supports this conclusion, which differs from the conclusions of previous work in other synapses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.