Evidence map›Paper›PMID 15042509›Full record

ArticleAmerican journal of human genetics2004

Phylogeographic analysis of haplogroup E3b (E-M215) y chromosomes reveals multiple migratory events within and out of Africa.

Fulvio Cruciani, Roberta La Fratta, Piero Santolamazza, Daniele Sellitto, Roberto Pascone, Pedro Moral, Elizabeth Watson, Valentina Guida, Eliane Beraud Colomb, Boriana Zaharova and 9 more

Abstract read
In one paragraph

Article in American journal of human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

63 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

19 authors.

Fulvio CrucianiDipartimento di Genetica e Biologia Molecolare, Universita "La Sapienza," 00185 Rome, Italy.
Roberta La Fratta
Piero Santolamazza
Daniele Sellitto
Roberto Pascone
Pedro Moral
Elizabeth Watson
Valentina Guida
Eliane Beraud Colomb
Boriana Zaharova
Joao Lavinha
Giuseppe Vona
Rashid Aman
Francesco Cali
Nejat Akar
Martin Richards
Antonio Torroni
Andrea Novelletto
Rosaria Scozzari

Funding

Telethon E.0890
6 · The paper itself

Abstract

We explored the phylogeography of human Y-chromosomal haplogroup E3b by analyzing 3401 individuals from five continents. Our data refine the phylogeny of the entire haplogroup, which appears as a collection of lineages with very different evolutionary histories, and reveal signatures of several distinct processes of migrations and/or recurrent gene flow that occurred in Africa and western Eurasia over the past 25000 years. In Europe, the overall frequency pattern of haplogroup E-M78 does not support the hypothesis of a uniform spread of people from a single parental Near Eastern population. The distribution of E-M81 chromosomes in Africa closely matches the present area of distribution of Berber-speaking populations on the continent, suggesting a close haplogroup-ethnic group parallelism. E-M34 chromosomes were more likely introduced in Ethiopia from the Near East. In conclusion, the present study shows that earlier work based on fewer Y-chromosome markers led to rather simple historical interpretations and highlights the fact that many population-genetic analyses are not robust to a poorly resolved phylogeny.

Indexed as

Emigration and ImmigrationPhylogenyAfricaChromosomes, Human, YEthnicityEuropeGene FrequencyGenetic VariationGeographyHaplotypesHumansMaleMiddle EastSiberiaTime Factors

Identifiers

PMID15042509
PMCPMC1181964

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.