ArticleBiophysical journal1992
Multiple conductances in the large K+ channel from Chara corallina shown by a transient analysis method.
Article in Biophysical journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Multi-Scale Characean Experimental System: From Electrophysiology of Membrane Transporters to Cell-to-Cell Connectivity, Cytoplasmic Streaming and Auxin Metabolism.Frontiers in plant science · 2016Review
- Statistical assessment of change point detectors for single molecule kinetic analysis.The Journal of membrane biology · 2013Article
- Single-channel basis for the slow activation of the repolarizing cardiac potassium current, I(Ks).Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Test of normality for integrated change point detection and mixture modeling.The Journal of membrane biology · 2013Article
- Article
- Restoration of single-channel currents using the segmental k-means method based on hidden Markov modeling.Biophysical journal · 2004Article
- Modeling diverse range of potassium channels with Brownian dynamics.Biophysical journal · 2002Article
- Nonselective currents and channels in plasma membranes of protoplasts from coats of developing seeds of bean.Plant physiology · 2002Article
- Article
- Time-irreversible subconductance gating associated with Ba2+ block of large conductance Ca2+-activated K+ channels.The Journal of general physiology · 1998Article
- Activation-dependent subconductance levels in the drk1 K channel suggest a subunit basis for ion permeation and gating.Biophysical journal · 1997Article
- Level detection in ion channel records via idealization by statistical filtering and likelihood optimization.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1997Article
- Subconductance states in single-channel activity of skeletal muscle ryanodine receptors after removal of FKBP12.Biophysical journal · 1997Article
- A new algorithm for idealizing single ion channel data containing multiple unknown conductance levels.Biophysical journal · 1996Article
- Rectifying conductance substates in a large conductance Ca(2+)-activated K+ channel: evidence for a fluctuating barrier mechanism.The Journal of general physiology · 1996Article
- Anion channels as central mechanisms for signal transduction in guard cells and putative functions in roots for plant-soil interactions.Plant molecular biology · 1995Review
- Ion channels in the plasma membrane of protoplasts from the halophytic angiosperm Zostera muelleri.The Journal of membrane biology · 1994Article
- The separation of exocytosis from endocytosis in rat melanotroph membrane capacitance records.The Journal of physiology · 1994Article
- Detection of jumps in single-channel data containing subconductance levels.Biophysical journal · 1994Article
- Testing for microscopic reversibility in the gating of maxi K+ channels using two-dimensional dwell-time distributions.Biophysical journal · 1994Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The large conductance K+ channel in the tonoplast of Chara corallina has subconductance states (substates). We describe a method that detects substates by monitoring the time derivative of channel current. Substates near to the full conductance tend to have long durations and high probabilities, while those of smaller amplitude occur with less probability and short duration. The substate pattern is similar in cell-attached, inside-out and outside-out patches over a range of temperatures. The pattern changes at high Ca2+ concentration (10 mol m-3) on the cytoplasmic face of inside-out patches. One substate at approximately 50% of the full conductance is characterized by a high frequency of transitions from the full conductance level. This midstate conductance is not a constant proportion of the full conductance but changes as a function of membrane potential difference (p.d.) showing strong inward rectification. We suggest that the channel is a single pore that can change conformation and/or charge profile to give different conductances. The mean durations of the full conductance level and the midstate decrease as the membrane p.d. becomes more negative. Programs for analysis of channel kinetics based on an half-amplitude detection criterion are shown to be unsuitable for analysis of the K+ channel.
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