ArticleLasers in medical science2004
Analysis of mitochondria, endoplasmic reticulum and actin filaments after PDT with AlPcS(4).
Article in Lasers in medical science, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Treatment of actinic cheilitis: a systematic review.Clinical oral investigations · 2019Pooled it
- Hypericin-mediated photodynamic therapy inhibits metastasis and EMT of colorectal cancer cells by regulating RhoA-ROCK1 signaling pathway.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024Article
- New Insights in Phenothiazinium-Mediated Photodynamic Inactivation of Candida Auris.Journal of fungi (Basel, Switzerland) · 2023Article
- Genotoxic effects of photodynamic therapy in laryngeal cancer cells - An in vitro study.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- Investigation of copper-cysteamine nanoparticles as a new photosensitizer for anti-hepatocellular carcinoma.Cancer biology & therapy · 2019Article
- A corrole nanobiologic elicits tissue-activated MRI contrast enhancement and tumor-targeted toxicity.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- Analysis of the in vivo and in vitro effects of photodynamic therapy on breast cancer by using a sensitizer, sinoporphyrin sodium.Theranostics · 2015Article
- Evaluation of photodynamic therapy in adhesion protein expression.Oncology letters · 2014Article
- Antitumor activity of photodynamic therapy performed with nanospheres containing zinc-phthalocyanine.Journal of nanobiotechnology · 2013Article
- Targets and mechanisms of photodynamic therapy in lung cancer cells: a brief overview.Cancers · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photodynamic therapy (PDT) is a therapeutic modality for the treatment of tumors. This technique uses a visible light to activate a photosensitizer compounds, leading to a photo-oxidation process of biological tissue that can induce apoptosis or necrosis both in vivo and in vitro. However many of the cytotoxic effects remain an open question to be investigated. The cytotoxicity to specific cellular targets of classical photosensitizers used in the PDT in vitro has been analyzed in this work. The photosensitizing effects of Chloroaluminum Phthalocyanine Tetrasulfonate (AlPcS(4)) were studied on the mitochondria, cytoskeleton and endoplasmic reticulum of HeLa cells. The cells were irradiated with a diode laser (working at 670 nm; energy density of 4.5 J/cm(2 )and power density of 45 mW/cm(2)). The spectrofluorimetric analysis of the mitochondria showed changes in membrane potential. Cytoskeleton and endoplasmic reticulum showed basic alterations in distribution after PDT treatment, as an indicator of cellular death process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.