ArticleJournal of molecular evolution2004
Phylogenetic analysis of Ciona intestinalis gene superfamilies supports the hypothesis of successive gene expansions.
Article in Journal of molecular evolution, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 37 citations in OpenAlex.
- The functional diversity of the POUV-class proteins across vertebrates.Open biology · 2022Review
- Whole Genome Duplications Shaped the Receptor Tyrosine Kinase Repertoire of Jawed Vertebrates.Genome biology and evolution · 2016Article
- Genome-Wide Identification and Transcriptome-Based Expression Profiling of the Sox Gene Family in the Nile Tilapia (Oreochromis niloticus).International journal of molecular sciences · 2016Article
- CSF-1 receptor signaling in myeloid cells.Cold Spring Harbor perspectives in biology · 2014Review
- Vascular Endothelial Growth Factor Receptor Family in Ascidians, Halocynthia roretzi (Sea Squirt). Its High Expression in Circulatory System-Containing Tissues.International journal of molecular sciences · 2013Article
- Parallel expansions of Sox transcription factor group B predating the diversifications of the arthropods and jawed vertebrates.PloS one · 2011Article
- The evolution of Fox genes and their role in development and disease.Nature reviews. Genetics · 2009Review
- Article
- Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy.Molecular systems biology · 2007Review
- A genome-wide survey of the evolutionarily conserved Wnt pathways in the sea urchin Strongylocentrotus purpuratus.Developmental biology · 2006Article
- Cataloging transcription factor and major signaling molecule genes for functional genomic studies in Ciona intestinalis.Development genes and evolution · 2005Article
- Genomic approaches reveal unexpected genetic divergence within Ciona intestinalis.Journal of molecular evolution · 2005Article
- Two rounds of whole genome duplication in the ancestral vertebrate.PLoS biology · 2005Article
- FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells.BMC genomics · 2005Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the formation of metazoan multigene families is a good approach to reconstitute the evolution of the chordate genome. In this attempt, the analysis of the genome of selected species provides valuable information. Ciona intestinalis belongs to the urochordates, whose lineage separated from the chordate lineage that later gave birth to vertebrates. We have searched available sequences from the small marine ascidian C. intestinalis for orthologs of members of five vertebrate superfamilies, including tyrosine kinase receptors, ETS, FOX and SOX transcription factors, and WNT secreted regulatory factors, and conducted phylogenetic analyses. We have found that most vertebrate subfamilies have a single C. intestinalis ortholog. Our results support the hypothesis of a gene expansion prior the base of chordate ancestry followed by another gene expansion during vertebrate evolution. They also indicate that Ciona intestinalis genome will be a very valuable tool for evolutionary analyses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.