Trial reportPsychopharmacology2004
Effects of serotonergic and noradrenergic antidepressants on auditory startle response in patients with major depression.
Trial report in Psychopharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Sertraline versus other antidepressive agents for depression.The Cochrane database of systematic reviews · 2010Pooled it
- Neurophysiological and clinical effects of the NMDA receptor antagonist lanicemine (BHV-5500) in PTSD: A randomized, double-blind, placebo-controlled trial.Depression and anxiety · 2021Trial
- Clonidine normalizes sensorimotor gating deficits in patients with schizophrenia on stable medication.Schizophrenia bulletin · 2013Trial
- Psilocybin-induced deficits in automatic and controlled inhibition are attenuated by ketanserin in healthy human volunteers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Trial
- The serotonin transporter gene and startle response during nicotine deprivation.Biological psychology · 2011Trial
- Effects of experimental acute tryptophan depletion on acoustic startle response in females.European archives of psychiatry and clinical neuroscience · 2008Trial
- Serotonin transporter gene variation impacts innate fear processing: Acoustic startle response and emotional startle.Molecular psychiatry · 2006Trial
- Opioid modulation of cognitive impairment in depression.Progress in brain research · 2018Review
- PREPULSE INHIBITION DEFICITS ONLY IN FEMALES WITH OBSESSIVE-COMPULSIVE DISORDER.Depression and anxiety · 2016Article
- The effect of alprazolam on acoustic stapedius reflex thresholds in healthy volunteers.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2014Article
- The effects of sertraline administration from adolescence to adulthood on physiological and emotional development in prenatally stressed rats of both sexes.Frontiers in behavioral neuroscience · 2014Article
- Impaired sensorimotor gating in unmedicated adults with obsessive-compulsive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Pharmacological stimulation of locus coeruleus reveals a new antipsychotic-responsive pathway for deficient sensorimotor gating.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Linking dimensional models of internalizing psychopathology to neurobiological systems: affect-modulated startle as an indicator of fear and distress disorders and affiliated traits.Psychological bulletin · 2009Review
- Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice.Biological psychiatry · 2009Article
- Profile of auditory information-processing deficits in schizophrenia.Psychiatry research · 2009Article
- The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits.Human molecular genetics · 2008Article
- Treatment consideration and manifest complexity in comorbid neuropsychiatric disorders.Neurotoxicity research · 2007Review
- The family of sensorimotor gating disorders: comorbidities or diagnostic overlaps?Neurotoxicity research · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleAmplitude, habituation and prepulse inhibition (PPI) of the acoustic startle response (ASR) in rodents and humans are sensitive to psychotropic drugs. Studies with rodents suggest that an increase or decrease in serotonin level in the brain alters several modalities of the ASR. So far, little is known about serotonergic and noradrenergic startle modulation in humans.
objectiveThis study was designed to investigate the effects of the selective serotonin uptake inhibitor sertraline versus the selective noradrenalin uptake inhibitor reboxetine on magnitude, habituation and PPI of ASR in patients with major depression.
methodsWe studied ASR in 23 patients with the diagnosis of major depression according to DSM-IV who were randomly treated either with sertraline or with reboxetine. Initially, ASR assessment was carried out when patients were drug-free for at least 2 weeks and again after 14 days of treatment.
resultsThe habituation of ASR was strongly attenuated by sertraline and not significantly altered by reboxetine. None of the substances altered the startle reactivity. In addition, PPI was not altered by sertraline, but reboxetine tended to decrease PPI. The startle reactivity at baseline was correlated with improvement of depressive symptoms at the end of the study.
conclusionThese results provide the first evidence for different effects of noradrenergic and serotonergic antidepressants on the startle response in depressed patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.