ArticleThe pharmacogenomics journal2004
Comprehensive expression analysis of a rat depression model.
Article in The pharmacogenomics journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 47 citations in OpenAlex.
- The Stress-Inducible Protein DRR1 Exerts Distinct Effects on Actin Dynamics.International journal of molecular sciences · 2018Article
- Differential and converging molecular mechanisms of antidepressants' action in the hippocampal dentate gyrus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Zinc signaling in the hippocampus and its relation to pathogenesis of depression.Molecular neurobiology · 2011Review
- cDNA microarray analysis of gene expression in the cerebral cortex and hippocampus of BALB/c mice subjected to chronic mild stress.Cellular and molecular neurobiology · 2010Article
- Expression profiling of a genetic animal model of depression reveals novel molecular pathways underlying depressive-like behaviours.PloS one · 2010Article
- Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine.Psychopharmacology · 2008Article
- Mitochondrial dysfunction as the molecular basis of bipolar disorder: therapeutic implications.CNS drugs · 2007Review
- Natural variation and genetic covariance in adult hippocampal neurogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Old principles in new clothes.The pharmacogenomics journal · 2004Article
- microRNAs as Biomarker in Depression Pathogenesis.Annals of psychiatry and mental healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herein we report on a large-scale analysis of gene expression in the 'learned helplessness' (LH) rat model of human depression, using DNA microarrays. We compared gene expression in the frontal cortex (FC) and hippocampus (HPC) of untreated controls, and LH rats treated with saline (LH-S), imipramine or fluoxetine. A total of 34 and 48 transcripts were differentially expressed in the FC and HPC, respectively, between control and LH-S groups. Unexpectedly, only genes for NADH dehydrogenase and zinc transporter were altered in both the FC and HPC, suggesting limited overlap in the molecular processes from specific areas of the brain. Principal component analysis revealed that sets of upregulated metabolic enzyme genes in the FC and downregulated genes for signal transduction in the HPC can distinguish clearly between depressed and control animals, as well as explain the responsiveness to antidepressants. This comprehensive data could help to unravel the complex genetic predispositions involved in human depression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.