ArticleProceedings of the National Academy of Sciences of the United States of America2004
Differential expression patterns of the hox gene are associated with differential growth of insect hind legs.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 60 citations in OpenAlex.
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- Evolutionary genomics of camouflage innovation in the orchid mantis.Nature communications · 2023Article
- Characterizing Hox genes in mayflies (Ephemeroptera), with Hexagenia limbata as a new mayfly model.EvoDevo · 2022Article
- CRISPR/Cas9-Mediated Mutagenesis ofInsects · 2022Article
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- A hemipteran insect reveals new genetic mechanisms and evolutionary insights into tracheal system development.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Changes throughout a Genetic Network Mask the Contribution of Hox Gene Evolution.Current biology : CB · 2019Article
- Hox genes and evolution.F1000Research · 2016Review
- Transcriptome analysis of sexually dimorphic Chinese white wax scale insects reveals key differences in developmental programs and transcription factor expression.Scientific reports · 2015Article
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- Ubx promotes corbicular development in Apis mellifera.Biology letters · 2014Article
- Hox gene expression leads to differential hind leg development between honeybee castes.PloS one · 2012Article
- Involvement of the conserved Hox gene Antennapedia in the development and evolution of a novel trait.EvoDevo · 2011Article
- Evolutionary reduction of the first thoracic limb in butterflies.Journal of insect science (Online) · 2011Article
- The expression of wingless and Engrailed in developing embryos of the mayfly Ephoron leukon (Ephemeroptera: Polymitarcyidae).Development genes and evolution · 2010Article
- Functional analysis of Scr during embryonic and post-embryonic development in the cockroach, Periplaneta americana.Developmental biology · 2010Article
- Evolution of a novel appendage ground plan in water striders is driven by changes in the Hox gene Ultrabithorax.PLoS genetics · 2009Article
- Diverging functions of Scr between embryonic and post-embryonic development in a hemimetabolous insect, Oncopeltus fasciatus.Developmental biology · 2009Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diversification of leg appendages is one of the hallmarks of morphological evolution in insects. In particular, insect hind (T3) legs exhibit a whole spectrum of morphological diversification, ranging from uniform to extremely modified. To elucidate the developmental basis of T3 leg evolution, we have examined the expression patterns of two homeotic genes, Ultrabithorax and abdominal-A (collectively referred to as UbdA), in a broad range of species. First, our results show that UbdA expression in hemimetabolous insects is localized only in specific T3 leg segments undergoing differential growth (compared to their foreleg counterparts). In contrast, in basal hexapod and insect lineages, the absence of the UbdA signal coincides with uniform leg morphology. The same situation exists in first instar larvae of holometabolous insects, in which absence of UbdA expression in the embryonic T3 legs is associated with the lack of larval T3 leg diversification. Second, there is a clear difference in the timing of expression between species with greatly enlarged T3 leg, such as crickets and grasshoppers, and species that exhibit more moderate enlargement of hind legs, such as mantids and cockroaches. In the former, the UbdA expression starts much earlier, coinciding with the elongation of T3 limb buds. In the latter, however, the UbdA expression starts at much later stages of development, coinciding with the establishment of distinct leg segments. These results suggest that diversification of insect hind legs was influenced by changes in both the spatial and temporal regulation of the UbdA expression.
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