ArticleBiophysical journal2004
Metastable network model of protein transport through nuclear pores.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Physics of the Nuclear Pore Complex: Theory, Modeling and Experiment.Physics reports · 2021Article
- Polymer translocation through a hairy channel mimicking the inner plug of a nuclear pore complex.European biophysics journal : EBJ · 2019Article
- Deciphering the Structure and Function of Nuclear Pores Using Single-Molecule Fluorescence Approaches.Journal of molecular biology · 2016Review
- Effect of charge, hydrophobicity, and sequence of nucleoporins on the translocation of model particles through the nuclear pore complex.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Systematic analysis of barrier-forming FG hydrogels from Xenopus nuclear pore complexes.The EMBO journal · 2013Article
- The yeast nuclear pore complex and transport through it.Genetics · 2012Article
- Simulations of nuclear pore transport yield mechanistic insights and quantitative predictions.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Brownian dynamics simulation of nucleocytoplasmic transport: a coarse-grained model for the functional state of the nuclear pore complex.PLoS computational biology · 2011Article
- A bimodal distribution of two distinct categories of intrinsically disordered structures with separate functions in FG nucleoporins.Molecular & cellular proteomics : MCP · 2010Article
- Dynamics of single mRNP nucleocytoplasmic transport and export through the nuclear pore in living cells.Nature cell biology · 2010Article
- Functionalization of a nanopore: the nuclear pore complex paradigm.Biochimica et biophysica acta · 2009Review
- Effects of jamming on nonequilibrium transport times in nanochannels.Physical review letters · 2009Article
- Global motions of the nuclear pore complex: insights from elastic network models.PLoS computational biology · 2009Article
- Nucleocytoplasmic transport: a thermodynamic mechanism.HFSP journal · 2009Article
- Intramolecular cohesion of coils mediated by phenylalanine--glycine motifs in the natively unfolded domain of a nucleoporin.PLoS computational biology · 2008Article
- Biology and biophysics of the nuclear pore complex and its components.International review of cell and molecular biology · 2008Review
- Efficiency, selectivity, and robustness of nucleocytoplasmic transport.PLoS computational biology · 2007Article
- Managing free-energy barriers in nuclear pore transport.Journal of biological physics · 2006Article
- Article
- Dynamics of transcription and mRNA export.Current opinion in cell biology · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To reconcile the observed selectivity and the high rate of translocation of cargo-importin complexes through nuclear pores, we propose that the core of the nuclear pore complex is blocked by a metastable network of phenylalanine and glycine nucleoporins. Although the network arrests the unfacilitated passage of objects larger than its mesh size, cargo-importin complexes act as catalysts that reduce the free energy barrier between the cross-linked and the dissociated states of the Nups, and open the network. Using Brownian dynamics simulations we calculate the distribution of passage times through the network for inert particles and cargo-importin complexes of different sizes and discuss the implications of our results for experiments on translocation of proteins through the nuclear pore complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.