ArticleWorld journal of gastroenterology2004
Clinical characteristics and management of patients with early acute severe pancreatitis: experience from a medical center in China.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 89 citations in OpenAlex.
- Early enteral nutrition prevents intra-abdominal hypertension and reduces the severity of severe acute pancreatitis compared with delayed enteral nutrition: a prospective pilot study.World journal of surgery · 2013Trial
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- Comparative Study Between Various Scoring Systems in Predicting the Severity of Acute Pancreatitis.Cureus · 2025Article
- GV-971 prevents severe acute pancreatitis by remodeling the microbiota-metabolic-immune axis.Nature communications · 2024Article
- Interventional Treatment of Abdominal Compartment Syndrome during Severe Acute Pancreatitis: Current Status and Historical Perspective.Gastroenterology research and practice · 2016Review
- Hypotension in the first week of acute pancreatitis and APACHE II score predict development of infected pancreatic necrosis.Digestive diseases and sciences · 2015Article
- Scoring of human acute pancreatitis: state of the art.Langenbeck's archives of surgery · 2013Review
- Effect of obesity and decompressive laparotomy on mortality in acute pancreatitis requiring intensive care unit admission.World journal of surgery · 2013Article
- Comparison of Ranson, Glasgow, MOSS, SIRS, BISAP, APACHE-II, CTSI Scores, IL-6, CRP, and Procalcitonin in Predicting Severity, Organ Failure, Pancreatic Necrosis, and Mortality in Acute Pancreatitis.HPB surgery : a world journal of hepatic, pancreatic and biliary surgery · 2013Article
- Clinical outcomes in patients with ICU-related pancreatitis.World journal of gastroenterology · 2009Article
- Intra-abdominal hypertension in acute pancreatitis.World journal of surgery · 2009Article
- Early recognition of abdominal compartment syndrome in patients with acute pancreatitis.World journal of gastroenterology · 2009Article
- Abdominal compartment syndrome in patients with severe acute pancreatitis in early stage.World journal of gastroenterology · 2008Article
- Severe acute pancreatitis: pathogenetic aspects and prognostic factors.World journal of gastroenterology · 2008Review
- Severe acute pancreatitis: Clinical course and management.World journal of gastroenterology · 2007Review
- Intense adrenal enhancement in patients with acute pancreatitis and early organ failure.Emergency radiology · 2007Article
- Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. II. Recommendations.Intensive care medicine · 2007Article
- Predicting severity of acute pancreatitis.Current gastroenterology reports · 2007Review
- Analysis of the clinical features of recurrent acute pancreatitis in China.Journal of gastroenterology · 2006Article
- Contemporary management of infected necrosis complicating severe acute pancreatitis.Critical care (London, England) · 2006Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study clinical characteristics and management of patients with early severe acute pancreatitis (ESAP).
methodsData of 297 patients with severe acute pancreatitis (SAP) admitted to our hospital within 72 h after onset of symptoms from January 1991 to June 2003 were reviewed for the occurrence and development of early severe acute pancreatitis (ESAP). ESAP was defined as presence of organ dysfunction within 72 h after onset of symptoms. Sixty-nine patients had ESAP, 228 patients without organ dysfunction within 72 h after onset of symptoms had SAP. The clinical characteristics, incidence of organ dysfunction during hospitalization and prognosis between ESAP and SAP were compared.
resultsImpairment degree of pancreas (Balthazar CT class) in ESAP was more serious than that in SAP (5.31+/-0.68 vs 3.68+/-0.29, P<0.01). ESAP had a higher mortality than SAP (43.4% vs 2.6%, P<0.01), and a higher incidence of hypoxemia (85.5% vs 25%, P<0.01), pancreas infection (15.9% vs 7.5%, P<0.05), abdominal compartment syndrome (ACS) (78.3% vs 23.2%, P<0.01) and multiple organ dysfunction syndrome (MODS)(78.3% vs 10.1%, P<0.01). In multiple logistic regression analysis, the main predisposing factors to ESAP were higher APACHE II score, Balthazar CT class, MODS and hypoxemia.
conclusionESAP is characterised by MODS, severe pathological changes of pancreas, early hypoxemia and abdominal compartment syndrome. Given the poor prognosis of ESAP, these patients should be treated in specialized intensive care units with special measures such as close supervision, fluid resuscitation, improvement of hypoxemia, reduction of pancreatic secretion, elimination of inflammatory mediators, prevention and treatment of pancreatic infections.
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