ArticleWorld journal of gastroenterology2004
Protective effect of exogenous adenosine triphosphate on hypothermically preserved rat liver.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Machine perfusion versus cold storage of livers: a meta-analysis.Frontiers of medicine · 2016Pooled it
- Small animalWorld journal of gastroenterology · 2026Review
- Adenosine 5'triphosphate transport and accumulation during the cold preservation of rat hepatocytes in University of Wisconsin solution.World journal of gastroenterology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo clarify the protective effect of exogenous adenosine triphosphate (ATP) on hypothermically preserved rat livers.
methodsEstablishment of continuous hypothermic machine perfusion model, detection of nucleotides in hepatocytes with HPLC, measurement of activities of LDH and AST in the perfusate, observation of histopathological changes in different experiment groups, and autoradiography were carried out to reveal the underlying mechanism of the protective effect of ATP.
resultsThe intracellular levels of ATP and EC decreased rapidly after hypothermic preservation in control group, while a higher ATP and EC level, and a slower decreasing rate were observed when ATP-MgCl(2) was added to the perfusate (P<0.01). As compared with the control group, the activities of LDH and AST in the ATP-MgCl(2) group were lower (P<0.05). Furthermore, more severe hepatocyte damage and neutrophil infiltration were observed in the control group. Radioactive [alpha-(32)P] ATP entered the hypothermically preserved rat hepatocytes.
conclusionExogenous ATP has a protective effect on rat livers during hypothermical preservation. However, Mg(2+) is indispensable, addition of ATP alone produces no protective effect. The underlying mechanism may be that exogenous ATP enters the hypothermically preserved rat liver cells.
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Registered trials
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