Evidence map›Paper›PMID 15039366›Full record

ArticleInfection and immunity2004

SKN7 of Candida albicans: mutant construction and phenotype analysis.

Praveen Singh, Neeraj Chauhan, Anup Ghosh, Freddie Dixon, Richard Calderone

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 109 citations in OpenAlex.

  1. A roadmap to chemically reactive species: how diverse oxidants affectMicrobiology and molecular biology reviews : MMBR · 2025
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  2. The regulatory network ofMicrobiology spectrum · 2025
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  6. Annual review of microbiology · 2023
    Review
  7. Review
  8. Oxidative stress response pathways in fungi.Cellular and molecular life sciences : CMLS · 2022
    Review
  9. Review
  10. Review
  11. The Roles of Chromatin Accessibility in Regulating theJournal of fungi (Basel, Switzerland) · 2021
    Review
  12. Review
  13. Nutrient and Stress Sensing in Pathogenic Yeasts.Frontiers in microbiology · 2019
    Review
  14. Article
  15. Article
  16. Article
  17. The yeasts phosphorelay systems: a comparative view.World journal of microbiology & biotechnology · 2017
    Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Praveen SinghDepartment of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA.
Neeraj Chauhan
Anup Ghosh
Freddie Dixon
Richard Calderone
Georgetown University · USGeorgetown University Medical Center · US

Funding

TWO-COMPONENT HISTIDINE KINASES OF CANDIDA ALBICANSR01AI043465 · NIAID · GEORGETOWN UNIVERSITY · PI CALDERONE, RICHARD ARTHUR · 2000 to 2009
$2.9M
RESPONSE REGULATOR GENE (CASSK1) OF CANDIDA ALBICANSR01AI047047 · NIAID · GEORGETOWN UNIVERSITY · PI CALDERONE, RICHARD ARTHUR · 2000 to 2004
$1.6M
NIAID NIH HHS AI 43465NIAID NIH HHS AI47047NIAID NIH HHS R01 AI043465NIAID NIH HHS R01 AI047047
6 · The paper itself

Abstract

The SKN7 two-component response regulator gene of Candida albicans was deleted, and the phenotype of the mutant was established. This mutant exhibited impaired growth on Spider agar and 10% serum agar compared to wild-type and gene-reconstituted strains. The skn7 mutant was sensitive to H(2)O(2) in vitro, but its virulence was only mildly attenuated. A comparison of the Skn7p and Ssk1p response regulators of C. albicans is discussed.

Indexed as

Gene DeletionSaccharomyces cerevisiae ProteinsAnimalsCandida albicansCandidiasisCulture MediaDisease Models, AnimalDNA-Binding ProteinsFungal ProteinsGene Expression Regulation, FungalHumansHydrogen PeroxideMiceOxidative StressPhenotypeSignal TransductionCulture MediaDNA-Binding ProteinsFungal ProteinsHydrogen PeroxideSaccharomyces cerevisiae ProteinsSKN7 protein, S cerevisiaeTranscription Factors

Identifiers

PMID15039366
PMCPMC375215
OpenAlexW2162559963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.