ArticleInfection and immunity2004
Flea-borne transmission model to evaluate vaccine efficacy against naturally acquired bubonic plague.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Vascular-associated bacterial burden and neuroinflammatory transcriptional responses observed in models of pneumonic plague.Frontiers in microbiology · 2026Article
- Experimental Infection of Ferrets withPathogens (Basel, Switzerland) · 2025Article
- A Role for Early-Phase Transmission in the Enzootic Maintenance of Plague.PLoS pathogens · 2022Article
- Does the arthropod microbiota impact the establishment of vector-borne diseases in mammalian hosts?PLoS pathogens · 2015Article
- The role of immune correlates and surrogate markers in the development of vaccines and immunotherapies for plague.Advances in preventive medicine · 2012Article
- Plague: Infections of Companion Animals and Opportunities for Intervention.Animals : an open access journal from MDPI · 2011Review
- Development of a vaccinia virus based reservoir-targeted vaccine against Yersinia pestis.Vaccine · 2010Article
- Delineation and analysis of chromosomal regions specifying Yersinia pestis.Infection and immunity · 2010Article
- Model systems to study plague pathogenesis and develop new therapeutics.Frontiers in microbiology · 2010Article
- Yersinia pestis IS1541 transposition provides for escape from plague immunity.Infection and immunity · 2009Article
- The Yersinia pestis caf1M1A1 fimbrial capsule operon promotes transmission by flea bite in a mouse model of bubonic plague.Infection and immunity · 2009Article
- Effect of adjuvants and route of immunizations on the immune response to recombinant plague antigens.Vaccine · 2007Article
- Delayed inflammatory response to primary pneumonic plague occurs in both outbred and inbred mice.Infection and immunity · 2007Article
- Protection against aerosolized Yersinia pestis challenge following homologous and heterologous prime-boost with recombinant plague antigens.Infection and immunity · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
A flea-to-mouse transmission model was developed for use in testing new candidate vaccines for the ability to protect against flea-borne plague. The model was used to evaluate a recombinant fusion protein vaccine consisting of the Yersinia pestis F1 and V antigens. After one to three challenges with Y. pestis-infected fleas, 14 of 15 unvaccinated control mice developed plague, with an average septicemia level of 9.2 x 10(8) Y. pestis CFU/ml. None of 15 vaccinated mice developed the disease after similar challenges, and serological testing indicated that transmitted bacteria were eliminated by the immune system before extensive replication and systemic infection could occur. The transmission and development of disease in control mice correlated with the number of bites by blocked fleas but not with the total number of fleabites. The model provides a means to directly assess the efficacy of new vaccines to prevent naturally acquired bubonic plague and to study events at the vector-host interface that lead to dissemination and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.