ArticleInfection and immunity2004
Immunoglobulin-mediated agglutination of and biofilm formation by Escherichia coli K-12 require the type 1 pilus fiber.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 67 citations in OpenAlex.
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- Anti-FimA monoclonal antibodies reveal dual roles in porphyromonas gingivalis pathogenesis.Journal of oral microbiology · 2026Article
- Relationship between Infant Feeding and the Microbiome: Implications for Allergies and Food Intolerances.Children (Basel, Switzerland) · 2024Review
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- Gut microbiome and breast-feeding: Implications for early immune development.The Journal of allergy and clinical immunology · 2022Review
- Characterization and antimicrobial susceptibility of biofilm-producing Avian Pathogenic Escherichia coli from broiler chickens and their environment in India.Veterinary research communications · 2022Article
- Roles of Secretory Immunoglobulin A in Host-Microbiota Interactions in the Gut Ecosystem.Frontiers in microbiology · 2022Review
- Diversity and dynamism of IgA-microbiota interactions.Nature reviews. Immunology · 2021Review
- Microbiota-antibody interactions that regulate gut homeostasis.Cell host & microbe · 2021Review
- Genotypic and Phenotypic Characteristics Associated with Biofilm Formation by Human Clinical Escherichia coli Isolates of Different Pathotypes.Applied and environmental microbiology · 2017Article
- The vermiform appendix and recurrent Clostridium difficile infection: a curious connection.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2011Article
- Recognition of gram-positive intestinal bacteria by hybridoma- and colostrum-derived secretory immunoglobulin A is mediated by carbohydrates.The Journal of biological chemistry · 2011Article
- Adaptation in a mouse colony monoassociated with Escherichia coli K-12 for more than 1,000 days.Applied and environmental microbiology · 2010Article
- Probiotic Lactobacillus reuteri biofilms produce antimicrobial and anti-inflammatory factors.BMC microbiology · 2009Article
- Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex.PloS one · 2008Article
- Functional analysis of pilQ gene in Xanthomonas oryzae pv. oryzae, bacterial blight pathogen of rice.Journal of microbiology (Seoul, Korea) · 2008Article
- Escherichia coli biofilms.Current topics in microbiology and immunology · 2008Review
- Article
- In vitro biofilm formation of commensal and pathogenic Escherichia coli strains: impact of environmental and genetic factors.Journal of bacteriology · 2006Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The binding of human secretory immunoglobulin A (SIgA), the primary immunoglobulin in the gut, to Escherichia coli is thought to be dependent on type 1 pili. Type 1 pili are filamentous bacterial surface attachment organelles comprised principally of a single protein, the product of the fimA gene. A minor component of the pilus fiber (the product of the fimH gene, termed the adhesin) mediates attachment to a variety of host cell molecules in a mannose inhibitable interaction that has been extensively described. We found that the aggregation of E. coli K-12 by human secretory IgA (SIgA) was dependent on the presence of the pilus fiber, even in the absence of the mannose specific adhesin or in the presence of 25 mM alpha-CH(3)Man. The presence of pilus without adhesin also facilitated SIgA-mediated biofilm formation on polystyrene, although biofilm formation was stronger in the presence of the adhesin. IgM also mediated aggregation and biofilm formation in a manner dependent on pili with or without adhesin. These findings indicate that the pilus fiber, even in the absence of the adhesin, may play a role in biologically important processes. Under conditions in which E. coli was agglutinated by SIgA, the binding of SIgA to E. coli was not increased by the presence of the pili, with or without adhesin. This observation suggests that the pili, with or without adhesin, affect factors such as cell surface rigidity or electrostatic repulsion, which can affect agglutination but which do not necessarily determine the level of bound immunoglobulin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.