ArticleThe American journal of pathology2004
Transit-amplifying ductular (oval) cells and their hepatocytic progeny are characterized by a novel and distinctive expression of delta-like protein/preadipocyte factor 1/fetal antigen 1.
Article in The American journal of pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- Progressive and Prognosis Value of Notch Receptors and Ligands in Hepatocellular Carcinoma: A Systematic Review and Meta-analysis.Scientific reports · 2017Pooled it
- IMT504 accelerates post-hepatectomy liver regeneration in mice with involvement of GLAST + Wnt1 + bone marrow stromal progenitors.Scientific reports · 2025Article
- Enrichment of trimethyl histone 3 lysine 4 in the Dlk1 and Grb10 genes affects pregnancy outcomes due to dietary manipulation of excess folic acid and low vitamin B12.Biological research · 2024Article
- "Small Hepatocytes" in the Liver.Cells · 2023Review
- Therapeutic Cell Repopulation of the Liver: From Fetal Rat Cells to Synthetic Human Tissues.Cells · 2023Review
- Update on Hepatobiliary Plasticity.Seminars in liver disease · 2023Article
- Founder cells for hepatocytes during liver regeneration: from identification to application.Cellular and molecular life sciences : CMLS · 2020Review
- Postnatal, ontogenic liver growth accomplished by biliary/oval cell proliferation and differentiation.PloS one · 2020Article
- Nrf2 Ameliorates DDC-Induced Sclerosing Cholangitis and Biliary Fibrosis and Improves the Regenerative Capacity of the Liver.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Yiguanjian decoction enhances fetal liver stem/progenitor cell-mediated repair of liver cirrhosis through regulation of macrophage activation state.World journal of gastroenterology · 2018Article
- Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity.Hepatology international · 2014Article
- Human fetal liver stromal cell co-culture enhances the differentiation of pancreatic progenitor cells into islet-like cell clusters.Stem cell reviews and reports · 2014Article
- Repopulation of the fibrotic/cirrhotic rat liver by transplanted hepatic stem/progenitor cells and mature hepatocytes.Hepatology (Baltimore, Md.) · 2014Article
- The origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells.Current topics in developmental biology · 2014Review
- Expansion of hepatic stem cell compartment boosts liver regeneration.Stem cells and development · 2014Article
- Molecular constituents of the extracellular matrix in rat liver mounting a hepatic progenitor cell response for tissue repair.Fibrogenesis & tissue repair · 2013Article
- Preadipocytes proliferate and differentiate under the guidance of Delta-like 1 homolog (DLK1).Adipocyte · 2013Article
- Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling.Genes & development · 2013Article
- Adult hair follicle stem cells do not retain the older DNA strands in vivo during normal tissue homeostasis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
- Hepatic stem cell niches.The Journal of clinical investigation · 2013Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatic regeneration from toxic or surgical injury to the adult mammalian liver, endorses different cellular responses within the hepatic lineage. The molecular mechanisms determining commitment of a cell population at a specific lineage level to participate in liver repair as well as the fate of its progeny in the hostile environment created by the injury are not well defined. Based on the role of the Notch/Delta/Jagged system in cell fate specification and recent reports linking Notch signaling with normal bile duct formation in mouse and human liver, we examined the expression of Notch1, Notch2, Notch3, Delta1, Delta3, Jagged1, and Jagged2, and delta-like protein/preadipocyte factor 1/fetal antigen 1 (dlk) in four well-defined experimental rat models of liver injury and regeneration. Although Delta3 and Jagged2 were undetectable by reverse transcriptase-polymerase chain reaction and Northern blot, we observed the most significant up-regulation of all other transcripts in the 2-acetylaminofluorene-70% hepatectomy (AAF/PHx) model, in which liver mass is restored by proliferation and differentiation of transit-amplifying ductular (oval) cells. The most profound change was observed for dlk. Accordingly, immunohistochemical analyses in the AAF/PHx model showed a specific expression of dlk in atypical ductular structures composed of oval cells. Delta-like protein was not observed in proliferating hepatocytes or bile duct cells after partial hepatectomy or ligation of the common bile duct whereas clusters of dlk immunoreactive oval cells were found in both the retrorsine and the AAF/PHx models. Finally, we used dlk to isolate alpha-fetoprotein-positive cells from fetal and adult regenerating rat liver by a novel antibody panning technique.
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