ArticleRNA (New York, N.Y.)2004
Loss of the mRNA-like region in mitochondrial tmRNAs of jakobids.
Article in RNA (New York, N.Y.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Expansion of the tmRNA sequence database and new tools for search and visualization.NAR genomics and bioinformatics · 2025Article
- Discovery of natural non-circular permutations in non-coding RNAs.Nucleic acids research · 2023Article
- Article
- The Origin and Evolution of Release Factors: Implications for Translation Termination, Ribosome Rescue, and Quality Control Pathways.International journal of molecular sciences · 2019Review
- Evolution of mitochondrial TAT translocases illustrates the loss of bacterial protein transport machines in mitochondria.BMC biology · 2018Article
- Comparative mitochondrial genomics of cryptophyte algae: gene shuffling and dynamic mobile genetic elements.BMC genomics · 2018Article
- A Comparative Analysis of Mitochondrial Genomes in Eustigmatophyte Algae.Genome biology and evolution · 2016Article
- Widespread occurrence of organelle genome-encoded 5S rRNAs including permuted molecules.Nucleic acids research · 2014Article
- Mechanism of trans-translation revealed by in vitro studies.Frontiers in microbiology · 2014Review
- tmRNA-mediated trans-translation as the major ribosome rescue system in a bacterial cell.Frontiers in genetics · 2014Review
- A second eukaryotic group with mitochondrion-encoded tmRNA: in silico identification and experimental confirmation.RNA biology · 2013Article
- Strikingly bacteria-like and gene-rich mitochondrial genomes throughout jakobid protists.Genome biology and evolution · 2013Article
- Mitochondrial evolution.Cold Spring Harbor perspectives in biology · 2012Review
- Yeast mitochondrial RNase P, RNase Z and the RNA degradosome are part of a stable supercomplex.Nucleic acids research · 2012Article
- Subcellular localization of a bacterial regulatory RNA.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Broad genomic and transcriptional analysis reveals a highly derived genome in dinoflagellate mitochondria.BMC biology · 2007Article
- Loss of a universal tRNA feature.Journal of bacteriology · 2007Article
- Hybrid E. coli--Mitochondrial ribonuclease P RNAs are catalytically active.RNA (New York, N.Y.) · 2006Article
- Cell cycle-regulated degradation of tmRNA is controlled by RNase R and SmpB.Molecular microbiology · 2005Article
- Evolutionary patterns of non-coding RNAs.Theory in biosciences = Theorie in den Biowissenschaften · 2005Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been postulated that a highly reduced form of transfer messenger RNA (tmRNA), a bacterial molecule involved in the rescue of stalled ribosomes during translation, is expressed in the mitochondrion of the jakobid Reclinomonas americana. Here we show that genes encoding both one-piece and two-piece tmRNAs are present in six different jakobid mitochondrial DNAs. Mitochondrial tmRNAs have retained the highly conserved tRNA(Ala)-like domain, but they apparently lack the mRNA-like region present in all bacterial tmRNAs. Comparative analysis of jakobid mitochondrial genomes shows that a potential mRNA-like region in R. americana (orf64) is located at distant genomic positions in other jakobids. Our results strongly suggest that orf64 is a tatA homolog. Through Northern hybridization we confirm the postulated reduced size of both a one-piece tmRNA in Jakoba libera and a two-piece tmRNA in Seculamonas ecuadoriensis. The J. libera tmRNA is post-transcriptionally modified by addition of a 3' CCA tail, processed in vitro by RNase P RNA, and specifically charged with alanine in vitro by alanyl-tRNA synthetase. Our results strongly support the functionality of these reduced mitochondrial tmRNAs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.