ArticleNucleic acids research2004
Quantitative oligonucleotide microarray fingerprinting of Salmonella enterica isolates.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Evaluation of one- and two-color gene expression arrays for microbial comparative genome hybridization analyses in routine applications.Journal of clinical microbiology · 2010Article
- Basic concepts of microarrays and potential applications in clinical microbiology.Clinical microbiology reviews · 2009Review
- Comprehensive DNA signature discovery and validation.PLoS computational biology · 2007Article
- A perspective on microarrays: current applications, pitfalls, and potential uses.Microbial cell factories · 2007Article
- Plant pathogen forensics: capabilities, needs, and recommendations.Microbiology and molecular biology reviews : MMBR · 2006Review
- Diagnostic oligonucleotide microarray fingerprinting of Bacillus isolates.Journal of clinical microbiology · 2006Article
- The theoretical basis of universal identification systems for bacteria and viruses.Journal of biological physics and chemistry : JBPC · 2005Article
- Application of oligonucleotide microarrays for bacterial source tracking of environmental Enterococcus sp. isolates.International journal of environmental research and public health · 2005Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report on a genome-independent microbial fingerprinting method using nucleic acid microarrays for microbial forensics and epidemiology applications and demonstrate that the microarray method provides high resolution differentiation between closely related microorganisms, using Salmonella enterica strains as the test case. In replicate trials we used a simple 192 probe nonamer array to construct a fingerprint library of 25 closely related Salmonella isolates. Controlling false discovery rate for multiple testing at alpha = 0.05, at least 295 of 300 pairs of S.enterica isolate fingerprints were found to be statistically distinct using a modified Hotelling T2 test. Although most pairs of Salmonella fingerprints are found to be distinct, forensic applications will also require a protocol for library construction and reliable microbial classification against a fingerprint library. We outline additional steps required to produce such a protocol.
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Registered trials
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