ReviewCurrent diabetes reports2004
Animal models of spontaneous autoimmune diabetes: notes on their relevance to the human disease.
Review in Current diabetes reports, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Mouse Models of Primary Sjogren's Syndrome.Current pharmaceutical design · 2015Review
- Current status and patent prospective of animal models in diabetic research.Advanced biomedical research · 2015Review
- Nonhuman primate models of type 1 diabetes mellitus for islet transplantation.Journal of diabetes research · 2014Review
- Proteomic changes associated with diabetes in the BB-DP rat.American journal of physiology. Endocrinology and metabolism · 2009Article
- VMAT2 gene expression and function as it applies to imaging beta-cell mass.Journal of molecular medicine (Berlin, Germany) · 2008Review
- Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model.The Journal of clinical investigation · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spontaneous autoimmune diabetes of the nonobese diabetic mouse and the BioBreeding diabetes-prone rat bears a striking similarity to human type 1 diabetes. For this reason it comes as a disappointment that interventions known to prevent the disease in the animal models proved ineffective in human trials. For an explanation I propose that, although the mechanism of beta-cell destruction is the same in the three species, this common mechanism may be the end point of different loss-of-tolerance pathways in different human patients, only two of which are represented by the two animal models. Research strategies to address this problem will require more attention to immune subphenotypes or their corresponding subgenotypes in the human and, possibly, the generation of additional mouse models of spontaneous disease.
Indexed as
Identifiers
15035976What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.