ArticleNeurogenetics2004
Evidence of linkage and association on chromosome 20 for late-onset Alzheimer disease.
Article in Neurogenetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Serum cystatin C is a potential predictor of short-term mortality and acute kidney injury in acute aortic dissection patients: a retrospective cohort study.Journal of thoracic disease · 2022Article
- Association BetweenFrontiers in neurology · 2021Article
- Cystatin C in aging and in Alzheimer's disease.Ageing research reviews · 2016Review
- Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study.Journal of the American College of Cardiology · 2016Article
- Cystatin C in Alzheimer's disease.Frontiers in molecular neuroscience · 2012Article
- Protective mechanisms by cystatin C in neurodegenerative diseases.Frontiers in bioscience (Scholar edition) · 2011Review
- Genetics of late-onset Alzheimer's disease: update from the alzgene database and analysis of shared pathways.International journal of Alzheimer's disease · 2011Article
- Phactr2 and Parkinson's disease.Neuroscience letters · 2009Article
- Exceptional brain aging in a rural population-based cohort.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2009Article
- APOE-4 genotype and neurophysiological vulnerability to Alzheimer's and cognitive aging.Annual review of clinical psychology · 2009Review
- Age-at-onset linkage analysis in Caribbean Hispanics with familial late-onset Alzheimer's disease.Neurogenetics · 2008Article
- A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population.American journal of human genetics · 2007Article
- The role of cystatin C in cerebral amyloid angiopathy and stroke: cell biology and animal models.Brain pathology (Zurich, Switzerland) · 2006Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Recently, we reported evidence of linkage on chromosome 20 for Alzheimer disease (AD) using a novel statistical approach to incorporate covariates (e.g., age, ApoE genotype) into the analysis. These results suggest that very elderly subjects (>85 years), and individuals who carry an epsilon2 allele at the ApoE locus are more likely to be linked to this candidate region. The region on chromosome 20 includes a strong candidate gene, cystatin C (CST3), which has previously been associated with AD in case-control studies. We investigated these findings further by genotyping additional markers to narrow the candidate region, and to identify evidence of linkage disequilibrium as additional support for a susceptibility locus on chromosome 20. We selected 43 elderly sibships (89 subjects) from the NIMH AD Genetics Initiative based on current age older than 84 years, and identified 129 unrelated control subjects who were older than 84 years from the Oregon Brain Aging Study to conduct linkage and association studies in this region. Fourteen additional markers were evaluated, including 4 markers located within or near CST3. We narrowed the candidate region on chromosome 20 to an 11.8-cM region between markers D20S174 and D20S471, which includes the CST3 candidate gene. In addition, we observed evidence of association for markers located near the CST3 candidate gene, with P values between 0.002 and 0.08 for two-locus haplotypes. These results support the presence of a susceptibility locus for AD in the vicinity of CST3 for very elderly subjects with AD.
Indexed as
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Registered trials
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