ArticleHistochemistry and cell biology2004
Localization of thrombomodulin in pericryptal fibroblasts of the rat duodenum.
Article in Histochemistry and cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
- News and views in Histochemistry and Cell Biology.Histochemistry and cell biology · 2004Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thrombomodulin (TM) contributes to the inactivation of thrombin which activates protein C, a major anticoagulant and anti-inflammatory protein. This report describes the distribution and localization of TM in the rat duodenum by light and electron microscopic immunohistochemistry. In addition to the endothelium of the entire vasculature, TM was found on the non-vascular structures, cellular networks of pericryptal fibroblasts surrounding the bases of the glandular crypts. TM was localized on the plasma membrane of the pericryptal fibroblasts which existed in the pericryptal spaces between the basal lamina of the epithelium and the collagenous sheets around the base of the crypt. TM-immunoreactive pericryptal fibroblasts were stellate-shaped cells and contacted with each other by their cytoplasmic processes forming an anastomosing syncytium around the base of the crypt. In contrast to pericryptal fibroblasts, TM was not localized in subepithelial fibroblasts in the villi or smooth muscle cells in the lamina muscularis mucosae and the muscularis. The functional significance of TM in pericryptal fibroblasts is discussed.
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