ArticleOncogene2004
Bcl-2 inhibition of T-cell proliferation is related to prolonged T-cell survival.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- RhCMV expands CCR5+ memory T cells and promotes SIV reservoir seeding in the gut mucosa.JCI insight · 2026Article
- Distinctive populations of CD4iScience · 2022Article
- Effects of Platycodin D on apoptosis, migration, invasion and cell cycle arrest of gallbladder cancer cells.Oncology letters · 2020Article
- Pre-sensitization of Malignant B Cells Through Venetoclax Significantly Improves the Cytotoxic Efficacy of CD19.CAR-T Cells.Frontiers in immunology · 2020Article
- Distinct IL-7 signaling in recent thymic emigrants versus mature naïve T cells controls T-cell homeostasis.European journal of immunology · 2016Article
- Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation.Cell death and differentiation · 2015Article
- T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity.eLife · 2014Article
- Sperm-borne microRNA-34c is required for the first cleavage division in mouse.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Identification of differentially expressed genes in human mesenchymal stem cell-derived neurons.Toxicological research · 2010Article
- Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation.Biochemical pharmacology · 2009Article
- Article
- G0 function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation by Mirk, revealing a novel role of BAX and BAK in quiescence regulation.The Journal of biological chemistry · 2008Article
- Microenvironmental considerations in the application of human mesenchymal stem cells in regenerative therapies.Biologics : targets & therapy · 2008Article
- Article
- Cell cycle dependency of caspase activation in Fas-induced apoptosis in leukemia cells.Cancer science · 2007Article
- Why G3139 works poorly in cancer trials but might work well against HIV.Medical hypotheses · 2007Article
- IL-7 promotes T cell proliferation through destabilization of p27Kip1.The Journal of experimental medicine · 2006Article
- Cytokine-driven cell cycling is mediated through Cdc25A.The Journal of cell biology · 2005Article
- Deletion of Bid impedes cell proliferation and hepatic carcinogenesis.The American journal of pathology · 2005Article
- The Pim kinases control rapamycin-resistant T cell survival and activation.The Journal of experimental medicine · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Bcl-2 promotes oncogenesis by inhibiting cell death. Bcl-2 also inhibits proliferation and suppresses tumorigenesis in some settings. To clarify the role of the antiproliferative function of Bcl-2, mice expressing a mutant form of Bcl-2 reported to lack antiproliferative activity were generated (tyrosine 28 to alanine, Bcl-2-Y28A). As expected, both wild type (WT) and Bcl-2-Y28A inhibited apoptosis similarly. In contrast to previous results in cell lines, Bcl-2-Y28A inhibited T-cell proliferation identical to WT-Bcl-2. Significantly, both Bcl-2-Y28A and WT-Bcl-2 inhibited proliferation of T cells isolated from older animals, but not proliferation of T cells from immature mice. Instead, inhibition of cell activation correlated with T-cell size, p27 levels, and RNA content, all indicators of quiescent G0 arrest. Consistent with this model, Bcl-2 inhibition of T-cell proliferation was reversed by expression of Bax, again correlating cell proliferation with cell size. These experiments do not support genetically separate effects of Bcl-2 on apoptosis and proliferation. Instead, the data support a model in which Bcl-2 and Bax regulate T-cell proliferation by changes in T-cell size and by increasing the markers of quiescent G0 arrest. These changes likely result from prolonged T-cell survival.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.