ArticleThe Journal of physiology2004
Excitability of the T-tubular system in rat skeletal muscle: roles of K+ and Na+ gradients and Na+-K+ pump activity.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- Metabolic alkalosis reduces exercise-induced acidosis and potassium accumulation in human skeletal muscle interstitium.The Journal of physiology · 2005Trial
- The impact of intradialytic cycling on temporal changes in muscle sodium during hemodialysis.Clinical kidney journal · 2026Article
- Exercise and fatigue: integrating the role of KEuropean journal of applied physiology · 2023Review
- A mouse model of Huntington's disease shows altered ultrastructure of transverse tubules in skeletal muscle fibers.The Journal of general physiology · 2021Article
- NHE- and diffusion-dependent proton fluxes across the tubular system membranes of fast-twitch muscle fibers of the rat.The Journal of general physiology · 2018Article
- Changes in contractile and metabolic parameters of skeletal muscle as rats age from 3 to 12 months.Journal of muscle research and cell motility · 2017Article
- Limitations in intense exercise performance of athletes - effect of speed endurance training on ion handling and fatigue development.The Journal of physiology · 2017Review
- Length-dependent Ca2+ activation in skeletal muscle fibers from mammalians.American journal of physiology. Cell physiology · 2016Article
- Article
- Effects of high-frequency stimulation and doublets on dynamic contractions in rat soleus muscle exposed to normal and high extracellular [K(+)].Physiological reports · 2013Article
- Effect of membrane properties on skeletal muscle fiber excitability: a sensitivity analysis.Medical & biological engineering & computing · 2012Article
- Influence of an alkalizing supplement on markers of endurance performance using a double-blind placebo-controlled design.Journal of the International Society of Sports Nutrition · 2012Article
- Distinct effects of subcellular glycogen localization on tetanic relaxation time and endurance in mechanically skinned rat skeletal muscle fibres.The Journal of physiology · 2009Article
- Rapid Ca2+ flux through the transverse tubular membrane, activated by individual action potentials in mammalian skeletal muscle.The Journal of physiology · 2009Article
- The accessibility and interconnectivity of the tubular system network in toad skeletal muscle.The Journal of physiology · 2008Article
- Do multiple ionic interactions contribute to skeletal muscle fatigue?The Journal of physiology · 2008Review
- Chloride conductance in the transverse tubular system of rat skeletal muscle fibres: importance in excitation-contraction coupling and fatigue.The Journal of physiology · 2008Article
- Potassium, Na+,K+-pumps and fatigue in rat muscle.The Journal of physiology · 2007Article
- Additive protective effects of the addition of lactic acid and adrenaline on excitability and force in isolated rat skeletal muscle depressed by elevated extracellular K+.The Journal of physiology · 2007Article
- Anomalous ion diffusion within skeletal muscle transverse tubule networks.Theoretical biology & medical modelling · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Strenuous exercise causes an increase in extracellular [K(+)] and intracellular Na(+) ([Na(+)](i)) of working muscles, which may reduce sarcolemma excitability. The excitability of the sarcolemma is, however, to some extent protected by a concomitant increase in the activity of muscle Na(+)-K(+) pumps. The exercise-induced build-up of extracellular K(+) is most likely larger in the T-tubules than in the interstitium but the significance of the cation shifts and Na(+)-K(+) pump for the excitability of the T-tubular membrane and the voltage sensors is largely unknown. Using mechanically skinned fibres, we here study the role of the Na(+)-K(+) pump in maintaining T-tubular function in fibres with reduced chemical K(+) gradient. The Na(+)-K(+) pump activity was manipulated by changing [Na(+)](i). The responsiveness of the T-tubules was evaluated from the excitation-induced force production of the fibres. Compared to control twitch force in fibres with a close to normal intracellular [K(+)] ([K(+)](i)), a reduction in [K(+)](i) to below 60 mM significantly reduced twitch force. Between 10 and 50 mM Na(+), the reduction in force depended on [Na(+)](i), the twitch force at 40 mM K(+) being 22 +/- 4 and 54 +/- 9% (of control force) at a [Na(+)](i) of 10 and 20 mM, respectively (n= 4). Double pulse stimulation of fibres at low [K(+)](i) showed that although elevated [Na(+)](i) increased the responsiveness to single action potentials, it reduced the capacity of the T-tubules to respond to high frequency stimulation. It is concluded that a reduction in the chemical gradient for K(+), as takes place during intensive exercise, may depress T-tubular function, but that a concomitant exercise-induced increase in [Na(+)](i) protects T-tubular function by stimulating the Na(+)-K(+) pump.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.