ArticleJournal of immunology (Baltimore, Md. : 1950)2004
Induction of a rapid and strong antigen-specific intraepithelial lymphocyte response during oral Encephalitozoon cuniculi infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Dysregulated IL-7/IL-7R-CD132 Axis and Intestinal Microsporidiosis in Crohn's Disease.Pathogens (Basel, Switzerland) · 2026Article
- Single-cell transcriptional responses of T cells during microsporidia infection.Communications biology · 2025Article
- Mutual Interactions Between Microbiota and the Human Immune System During the First 1000 Days of Life.Biology · 2025Review
- Ligands for Intestinal Intraepithelial T Lymphocytes in Health and Disease.Pathogens (Basel, Switzerland) · 2025Review
- The Role of Lipids in the Regulation of Immune Responses.Nutrients · 2023Review
- Intestinal homeostasis in the gut-lung-kidney axis: a prospective therapeutic target in immune-related chronic kidney diseases.Frontiers in immunology · 2023Review
- Immune Response to Microsporidia.Experientia supplementum (2012) · 2022Article
- Chronic Infections in Mammals Due to Microsporidia.Experientia supplementum (2012) · 2022Article
- High Frequency ofJournal of fungi (Basel, Switzerland) · 2021Article
- Characterization of humoral and cell-mediated immunity in rabbits orally infected with Encephalitozoon cuniculi.Veterinary research · 2020Article
- Innate and Adaptive Immune Responses Against Microsporidia Infection in Mammals.Frontiers in microbiology · 2020Review
- Encephalitozoon: Tissue Culture, Cryopreservation, and Murine Infection.Current protocols in microbiology · 2019Article
- Cyclophosphamide Treatment Mimics Sub-Lethal Infections WithFrontiers in microbiology · 2019Article
- Microsporidia: Obligate Intracellular Pathogens Within the Fungal Kingdom.Microbiology spectrum · 2017Review
- Article
- Interaction between the gut microbiome and mucosal immune system.Military Medical Research · 2017Review
- IL-21 Is Important for Induction of KLRG1+ Effector CD8 T Cells during Acute Intracellular Infection.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Interleukin-12-producing CD103+ CD11b- CD8+ dendritic cells are responsible for eliciting gut intraepithelial lymphocyte response against Encephalitozoon cuniculi.Infection and immunity · 2015Article
- CD8+ T cell immune response against non-viral pathogens.Seminars in immunopathology · 2015Article
- Effector CD8 T cell immunity in microsporidial infection: a lone defense mechanism.Seminars in immunopathology · 2015Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Encephalitozoon cuniculi continues to pose a problem for immunocompromised patients. Previous studies from our laboratory have elucidated the importance of the CD8(+) T cell subset in the protection against systemic parasite infection. There have been no studies related to the mucosal immunity induced against this orally acquired pathogen. In the present study, the immune response generated in the gut after oral E. cuniculi infection was evaluated. An early and rapid increase of the intraepithelial lymphocyte (IEL) population of orally infected animals was observed. This increase in the IEL population started as early as day 3 and peaked at day 7 postinfection with persistent elevation thereafter. At day 7 postinfection, IELs expressed strong cytokine messages (IFN-gamma and IL-10) and were highly cytotoxic for parasite-infected syngeneic macrophages. At an E:T ratio of 80:1, these cells were able to cause >60% Ag-specific target cell lysis. A significant increase in the CD8alphaalpha subset of IEL in response to an oral E. cuniculi infection was observed. To the best of our knowledge, such an early expansion of an IEL population exhibiting strong ex vivo cytotoxicity has not been reported with infectious models. These data suggest that IELs act as important barriers for multiplication of this organism leading to the successful resolution of infection. The protective role of IELs may be due both to their inflammatory (IFN-gamma production and cytotoxic response) as well as immunoregulatory (IL-10 production) properties.
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Registered trials
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