ArticleEndocrinology2004
Rhythmic secretion of prolactin in rats: action of oxytocin coordinated by vasoactive intestinal polypeptide of suprachiasmatic nucleus origin.
Article in Endocrinology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 88 citations in OpenAlex.
- Prolactin and oxytocin: potential targets for migraine treatment.The journal of headache and pain · 2023Review
- Dynamic Regulation of JAK-STAT Signaling Through the Prolactin Receptor Predicted by Computational Modeling.Cellular and molecular bioengineering · 2021Article
- The Prolactin Family of Hormones as Regulators of Maternal Mood and Behavior.Frontiers in global women's health · 2021Review
- Localization of Vasoactive Intestinal Polypeptide Receptor 1 (VPAC1) in Hypothalamic Neuroendocrine Oxytocin Neurons; A Potential Role in Circadian Prolactin Secretion.Frontiers in neuroanatomy · 2020Article
- Secretion and Function of Pituitary Prolactin in Evolutionary Perspective.Frontiers in neuroscience · 2020Review
- Circadian Regulation of the Brain and Behavior: A Neuroendocrine Perspective.Current topics in behavioral neurosciences · 2019Article
- Circadian Control of Neuroendocrine Function: Implications for Health and Disease.Current opinion in physiology · 2018Article
- The role of the circadian clock system in physiology.Pflugers Archiv : European journal of physiology · 2018Review
- Isotocin Regulates Growth Hormone but Not Prolactin Release From the Pituitary of Ricefield Eels.Frontiers in endocrinology · 2018Article
- Prolactin regulation of oxytocin neurone activity in pregnancy and lactation.The Journal of physiology · 2017Article
- Collective timekeeping among cells of the master circadian clock.The Journal of endocrinology · 2016Review
- Circadian Tick-Talking Across the Neuroendocrine System and Suprachiasmatic Nuclei Circuits: The Enigmatic Communication Between the Molecular and Electrical Membrane Clocks.Journal of neuroendocrinology · 2015Review
- Direct stimulatory effects of oxytocin in female rat gonadotrophs and somatotrophs in vitro: comparison with lactotrophs.Endocrinology · 2015Article
- Neuroanatomy of the extended circadian rhythm system.Experimental neurology · 2013Review
- Central circadian control of female reproductive function.Frontiers in endocrinology · 2013Review
- Aging differentially affects the re-entrainment response of central and peripheral circadian oscillators.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Cervical stimulation activates A1 and locus coeruleus neurons that project to the paraventricular nucleus of the hypothalamus.Brain research bulletin · 2012Article
- Oxytocin: an emerging regulator of prolactin secretion in the female rat.Journal of neuroendocrinology · 2012Article
- Circadian control of neuroendocrine circuits regulating female reproductive function.Frontiers in endocrinology · 2012Article
- Prolactin induces a hyperpolarising current in rat paraventricular oxytocinergic neurones.Journal of neuroendocrinology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Prolactin (PRL) is secreted from lactotrophs of the anterior pituitary gland of rats in a unique pattern in response to uterine cervical stimulation (CS) during mating. Surges of PRL secretion occur in response to relief from hypothalamic dopaminergic inhibition and stimulation by hypothalamic releasing neurohormones. In this study, we characterized the role of oxytocin (OT) in this system and the involvement of vasoactive intestinal polypeptide (VIP) from the suprachiasmatic nucleus (SCN) in controlling OT and PRL secretion of CS rats. The effect of OT on PRL secretion was demonstrated in cultured lactotrophs showing simultaneous enhanced secretion rate and increased intracellular Ca(2+). Neurosecretory OT cells of the hypothalamic paraventricular nucleus that express VIP receptors were identified by using immunocytochemical techniques in combination with the retrogradely transported neuronal tracer Fluoro-Gold (iv injected). OT measurements of serial blood samples obtained from ovariectomized (OVX) CS rats displayed a prominent increase at the time of the afternoon PRL peak. The injection of VIP antisense oligonucleotides into the SCN abolished the afternoon increase of OT and PRL in CS-OVX animals. These findings suggest that VIP from the SCN contributes to the regulation of OT and PRL secretion in CS rats. We propose that in CS rats the regulatory mechanism(s) for PRL secretion comprise coordinated action of neuroendocrine dopaminergic and OT cells, both governed by the daily rhythm of VIP-ergic output from the SCN. This hypothesis is illustrated with a mathematical model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.