ArticleJournal of clinical immunology2003
Vaccination with rabies to study the humoral and cellular immune response to a T-cell dependent neoantigen in man.
Article in Journal of clinical immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Antiretroviral therapy interruptions result in loss of protective humoral immunity to neoantigens in HIV-infected individuals.AIDS (London, England) · 2012Trial
- Plasma and memory B-cell kinetics in infants following a primary schedule of CRM 197-conjugated serogroup C meningococcal polysaccharide vaccine.Immunology · 2009Trial
- Anticentromere Antibody Levels and Isotypes and the Development of Systemic Sclerosis.Arthritis & rheumatology (Hoboken, N.J.) · 2021Article
- Modeling human adaptive immune responses with tonsil organoids.Nature medicine · 2021Article
- Review
- An unusual presentation of a patient with severe hypogammaglobulinemia.Clinical case reports · 2018Article
- Recombinant outer membrane protein C of Aeromonas hydrophila elicits mixed immune response and generates agglutinating antibodies.Immunologic research · 2016Article
- Randomized study of teriflunomide effects on immune responses to neoantigen and recall antigens.Neurology(R) neuroimmunology & neuroinflammation · 2015Article
- New diagnostic criteria for common variable immune deficiency (CVID), which may assist with decisions to treat with intravenous or subcutaneous immunoglobulin.Clinical and experimental immunology · 2013Review
- CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia.The Journal of allergy and clinical immunology · 2012Article
- B-cell maturation and antibody responses in individuals carrying a mutated CD19 allele.Genes and immunity · 2010Article
- Experimental rabies vaccines for humans.Expert review of vaccines · 2010Review
- Article
- Resetting the adaptive immune system after autologous stem cell transplantation: lessons from responses to vaccines.Journal of clinical immunology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the humoral (antigen-specific immunoglobulin isotypes, IgG subclasses, and avidity maturation) and cellular (antigen-specific in vitro proliferation) immune response in 18 healthy adult volunteers, following a primary and a single booster vaccination with the T-cell dependent neoantigen rabies administered at a 3-months interval. The IgG antibody titer showed a mean 31-fold increase (range 3-154) 4 weeks after the first vaccination and a memory response was observed after booster vaccination, i.e. high IgG titers, switch from IgM to IgG and IgA and increased antibody avidity. All healthy adults showed a rabies-induced proliferative response with a mean stimulation index of 45 (range 3.5-200) after in vitro stimulation of PBMC obtained at 4 weeks after booster vaccination. The results obtained in this study provide a frame of reference for the interpretation of specific immune responses to the T-cell dependent neoantigen rabies in patients suspected of a primary or secondary immunodeficiency. Humoral and cellular immune responses to the rabies neoantigen provide complementary information on the condition of the immune system of an individual. Five patients diagnosed with a combined immunodeficiency were vaccinated using the same protocol and showed a number of abnormalities, either in the humoral or the cellular immune response to the rabies neoantigen.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.