ArticleJournal of clinical immunology2003
Analysis of the expression of MICA in small intestinal mucosa of patients with celiac disease.
Article in Journal of clinical immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 29 citations in OpenAlex.
- Adaptations of lipid metabolism in low-grade clear cell renal cell carcinoma are linked to cholesteryl ester accumulation.Scientific reports · 2025Article
- Transcription Factor Binding Site Enrichment Analysis in Co-Expression Modules in Celiac Disease.Genes · 2018Article
- Evaluation of European coeliac disease risk variants in a north Indian population.European journal of human genetics : EJHG · 2015Article
- Coregulation and modulation of NFκB-related genes in celiac disease: uncovered aspects of gut mucosal inflammation.Human molecular genetics · 2014Article
- Autoantibodies against MHC class I polypeptide-related sequence A are associated with increased risk of concomitant autoimmune diseases in celiac patients.BMC medicine · 2014Article
- Broad MICA/B expression in the small bowel mucosa: a link between cellular stress and celiac disease.PloS one · 2013Article
- The NKG2D receptor: immunobiology and clinical implications.Immunologic research · 2008Review
- MICA response to gliadin in intestinal mucosa from celiac patients.Immunogenetics · 2004Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The MHC class I chain-related A gene (MICA) is expressed in gastrointestinal epithelium and functions as an immune activation signal under stress conditions. MICA protein binds to NKG2D, a receptor of gamma delta T cells containing the TCR variable region V(delta)1, which are the most abundant subset of T cells in the intestinal epithelium. Ingested gluten in patients with celiac disease (CD) may function as a stress signal for the epithelial cells, and could enhance MICA expression on their surface. In this study, we have analyzed MICA expression in intestinal biopsy specimens from newly diagnosed and treated CD patients and controls. Quantitative RT-PCR analysis did not show differences in MICA expression among the three groups. With these results, we conclude that overexpression of MICA does not seem to play an important role in the pathogenesis of CD, at least at the time of diagnosis.
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