ArticleJournal of clinical immunology2003
Gold sodium thiomalate and chloroquine inhibit cytokine production in monocytic THP-1 cells through distinct transcriptional and posttranslational mechanisms.
Article in Journal of clinical immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Impact of repurposed drugs on the symptomatic COVID-19 patients.Journal of infection and public health · 2021Review
- Insights into antiviral mechanisms of remdesivir, lopinavir/ritonavir and chloroquine/hydroxychloroquine affecting the new SARS-CoV-2.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020Review
- Hydroxychloroquine and chloroquine in COVID-19: should they be used as standard therapy?Clinical rheumatology · 2020Review
- The possible mechanisms of action of 4-aminoquinolines (chloroquine/hydroxychloroquine) against Sars-Cov-2 infection (COVID-19): A role for iron homeostasis?Pharmacological research · 2020Review
- SARS-CoV-2, ACE2, and Hydroxychloroquine: Cardiovascular Complications, Therapeutics, and Clinical Readouts in the Current Settings.Pathogens (Basel, Switzerland) · 2020Review
- COVID-19, an opportunity to reevaluate the correlation between long-term effects of anthropogenic pollutants on viral epidemic/pandemic events and prevalence.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020Review
- Smooth or Risky Revisit of an Old Malaria Drug for COVID-19?Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Review
- The role of growth factor receptors in viral infections: An opportunity for drug repurposing against emerging viral diseases such as COVID-19?FASEB bioAdvances · 2020Article
- New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?International journal of antimicrobial agents · 2020Article
- Molecular Insights into the MAPK Cascade during Viral Infection: Potential Crosstalk between HCQ and HCQ Analogues.BioMed research international · 2020Review
- Hydroxychloroquine in COVID-19 Patients: Pros and Cons.Frontiers in pharmacology · 2020Review
- Article
- Gold(I) complexes of 9-deazahypoxanthine as selective antitumor and anti-inflammatory agents.PloS one · 2014Article
- Article
- Auranofin protects against anthrax lethal toxin-induced activation of the Nlrp1b inflammasome.Antimicrobial agents and chemotherapy · 2011Article
- Perioperative management of immunosuppression in rheumatic diseases--what to do?Rheumatology international · 2010Review
- IL-10 and TNFalpha genotypes in SLE.Journal of biomedicine & biotechnology · 2010Review
- [Gold. Effective therapy for mucosal lesions of pemphigus vulgaris].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2007Article
- Cytokine polymorphisms influence treatment outcomes in SLE patients treated with antimalarial drugs.Arthritis research & therapy · 2006Article
- The modulation of intra-articular inflammation, cartilage matrix and bone loss in mono-articular arthritis induced by heat-killed Mycobacterium tuberculosis.Inflammopharmacology · 2005Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Gold sodium thiomalate (GST), chloroquine (CQ), and methotrexate have been widely used in the therapy of rheumatoid arthritis and other inflammatory conditions. Using the human monocytic cell line THP-1 we have analyzed effects of these drugs on cytokine production and intracellular signaling. GST and CQ were equally effective in reducing lipopolysaccharide (LPS)-induced IL-1 beta release while CQ was a more effective inhibitor of TNF-alpha production than GST. Methotrexate did not affect production of these cytokines. CQ reduced IL-1 beta mRNA expression and strongly inhibited phosphorylation of mitogen-activated protein kinase (MAPK) p38, and to a lesser extent c-Jun N-terminal kinase and extracellular signal-regulated kinase 1/2. In contrast, GST did not affect cytokine mRNA expression or MAPK activation. However, GST selectively inhibited the activity of the interleukin-1 converting enzyme (ICE)/caspase-1. These data demonstrate that CQ inhibits IL-1 beta release from monocytes by interfering with pretranscriptional signaling and TNF-alpha release by posttranslational events whereas GST downregulates IL-1 beta secretion by interfering with posttranslational IL-1 beta processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.