Evidence map›Paper›PMID 15031403›Full record

SynthesisOccupational and environmental medicine2004

Biomarkers of exposure to polycyclic aromatic hydrocarbons from environmental air pollution.

G Castaño-Vinyals, A D'Errico, N Malats, M Kogevinas

Open access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in Occupational and environmental medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 192 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
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  6. Update in Association between Lung Cancer and Air Pollution.Tuberculosis and respiratory diseases · 2025
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

G Castaño-VinyalsRespiratory and Environmental Research Unit, Municipal Institute of Medical Research, Barcelona, Spain.
A D'Errico
N Malats
M Kogevinas
Municipal Institute for Medical Research · ESRegione Piemonte

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolites of pyrene and DNA adducts have been used as biomarkers of high level exposure to polycyclic aromatic hydrocarbons (PAHs). A systematic review was performed to evaluate whether these biomarkers are also valid markers of low level environmental exposure to PAHs. Thirty five studies were identified with more than 10 subjects that evaluated environmental air pollution to PAHs in relation to metabolites of PAHs, mainly hydroxypyrene (1-OHP), PAH-DNA adducts, or protein adducts. PAH metabolites and, to a less extent, PAH-DNA adducts correlated well at the group level with exposure to B(a)P even at low levels of air pollution. The use of these biomarkers should be more widely implemented in combination with more traditional techniques for the assessment of general population exposure to PAHs from ambient air pollution.

Indexed as

Air PollutantsBiomarkersDNA AdductsHumansPolycyclic Aromatic HydrocarbonsPyrenes1-hydroxypyreneAir PollutantsBiomarkersDNA AdductsPolycyclic Aromatic Hydrocarbonspolycyclic aromatic hydrocarbons-DNA adductPyrenes

Identifiers

PMID15031403
PMCPMC1740739
OpenAlexW1971388262

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.