ArticleThe British journal of ophthalmology2004
Normal tension glaucoma is not associated with the common apolipoprotein E gene polymorphisms.
Article in The British journal of ophthalmology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
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The trial behind it
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Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Apolipoprotein E gene ε4ε4 is associated with elevated risk of primary open angle glaucoma in Asians: a meta-analysis.BMC medical genetics · 2014Pooled it
- An updated meta-analysis: apolipoprotein E genotypes and risk of primary open-angle glaucoma.Molecular vision · 2014Pooled it
- Role of the APOE ε2/ε3/ε4 polymorphism in the development of primary open-angle glaucoma: evidence from a comprehensive meta-analysis.PloS one · 2013Pooled it
- Pooled it
- Exploring the role of apolipoprotein E gene promoter polymorphisms in susceptibility to normal-tension glaucoma in a Korean population.Scientific reports · 2024Article
- Association of APOE Haplotypes With Common Age-Related Ocular Diseases in 412,171 Individuals.Investigative ophthalmology & visual science · 2023Article
- No Strong Association between the Apolipoprotein E E4 Allele and Glaucoma: A Multicohort Study.Ophthalmology science · 2023Article
- Apolipoprotein ε in Brain and Retinal Neurodegenerative Diseases.Aging and disease · 2023Review
- TheOphthalmology science · 2022Article
- Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE ε4.Investigative ophthalmology & visual science · 2020Article
- Neurosteroids and oxysterols as potential therapeutic agents for glaucoma and Alzheimer's disease.Neuropsychiatry · 2018Article
- An Updated Review on the Genetics of Primary Open Angle Glaucoma.International journal of molecular sciences · 2015Review
- Current concepts on primary open-angle glaucoma genetics: a contribution to disease pathophysiology and future treatment.Eye (London, England) · 2012Review
- Complex genetic mechanisms in glaucoma: an overview.Indian journal of ophthalmology · 2011Review
- Alzheimer's disease and primary open-angle glaucoma: is there a connection?Clinical ophthalmology (Auckland, N.Z.) · 2011Article
- Association of polymorphisms in APOE, p53, and p21 with primary open-angle glaucoma in Turkish patients.Molecular vision · 2009Article
- Investigation of the association between the GLC3A locus and normal tension glaucoma in Japanese patients by microsatellite analysis.Clinical ophthalmology (Auckland, N.Z.) · 2009Article
- Apolipoprotein E polymorphisms and primary glaucoma in Saudis.Molecular vision · 2009Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background/aims: In normal tension glaucoma (NTG) factors other than raised intraocular pressure have a role in the pathogenesis of the optic neuropathy. Because particular apolipoprotein E (ApoE) gene polymorphisms have been associated with cell death and survival in neurological degenerative diseases, the purpose of this study was to determine the ApoE allele frequencies in patients with normal tension glaucoma.
methodsThe apolipoprotein E genotype of 155 patients with normal tension glaucoma was compared to that of 349 non-affected, control subjects from the same geographical area. A similar comparison was made between 53 patients with normal tension glaucoma who demonstrated progressive visual field loss, and control subjects. The frequencies of genotypes was compared with the chi(2) test and Mantel-Haenszel coefficent.
resultsThere was no significant difference in the frequency of ApoE alleles or genotypes in the normal tension glaucoma population compared to the control group. The ApoE alleles and genotypes in NTG patients with progressive disease were not different from the control group.
conclusionApoE gene polymorphisms are not linked to normal tension glaucoma, suggesting that this gene does not have a role in the pathogenesis of optic neuropathy in this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.