ArticleClinical and experimental immunology2004
The membrane attack complex, C5b-9, up regulates collagen gene expression in renal tubular epithelial cells.
Article in Clinical and experimental immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Tubulointerstitial inflammation and fibrosis induced by proteinuria: fresh insights.Frontiers in pharmacology · 2026Review
- Regulation of the terminal complement cascade in adipose tissue for control of its volume, cellularity, and fibrosis.Obesity (Silver Spring, Md.) · 2025Review
- Authors' Reply: Complement Inhibition Therapy in IgA Nephropathy: Total or Selective Inhibition?Journal of the American Society of Nephrology : JASN · 2025Article
- The complement pathway and the pathophysiology of fibroproliferative cutaneous scarring.Frontiers in immunology · 2025Review
- Apical tubular complement activation and the loss of kidney function in proteinuric kidney diseases.Clinical kidney journal · 2024Review
- Acute Kidney Injury in Kidney Transplant Patients in Intensive Care Unit: From Pathogenesis to Clinical Management.Biomedicines · 2023Review
- The Complement System in Kidney Transplantation.Cells · 2023Review
- The role of the complement system in primary membranous nephropathy: A narrative review in the era of new therapeutic targets.Frontiers in immunology · 2022Review
- Inflammaging and Complement System: A Link Between Acute Kidney Injury and Chronic Graft Damage.Frontiers in immunology · 2020Review
- Ischaemia reperfusion injury: mechanisms of progression to chronic graft dysfunction.Pediatric nephrology (Berlin, Germany) · 2019Review
- Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress.Scientific reports · 2017Article
- Complement activation in progressive renal disease.World journal of nephrology · 2015Review
- Inflammatory processes in renal fibrosis.Nature reviews. Nephrology · 2014Review
- Overview of complement activation and regulation.Seminars in nephrology · 2013Review
- Heat shock protein 70 and albuminuria in patients with type 2 diabetes: a matched case control study.Cell stress & chaperones · 2013Article
- Quantitative and qualitative urinary cellular patterns correlate with progression of murine glomerulonephritis.PloS one · 2011Article
- Etiopathology of chronic tubular, glomerular and renovascular nephropathies: clinical implications.Journal of translational medicine · 2011Review
- C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy.Journal of the American Society of Nephrology : JASN · 2009Article
- The profile of gene expression and role of nuclear factor kappa B on glomerular injury in rats with Thy-1 nephritis.Clinical and experimental immunology · 2008Article
- Complement in glomerular injury.Seminars in immunopathology · 2007Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence suggesting a direct role for proteinuria in the pathogenesis of renal tubulointerstitial fibrosis is accumulating. However the mechanism by which proteinuria leads to injury is unknown. In proteinuric states complement proteins are filtered through the glomerulus and could contribute to the tubular damage. The aim of this study was to investigate the role of complement activation in the progression of interstitial fibrosis. To determine whether complement activation may be responsible for the pro-fibrotic response that occurs in the tubulointerstitial compartment we stimulated primary cultures of proximal tubular epithelial cells with membrane attack complex, C5b-9. This led to increased mRNA concentrations of both collagen type IV and its intracellular chaperone, Heat Shock Protein 47 (HSP47). To determine whether this occurred in vivo Adriamycin was used to induce proteinuria in female Balb/c mice. The expression of collagen type IV and HSP47 was increased in proteinuric mice compared to control mice. In proteinuric mouse kidney, C3 was deposited at sites of tubulointerstitial injury and there was a relationship between C3 deposition and immunochemical staining for collagen type IV and HSP47. In situ hybridization suggested that the renal tubular epithelium was actively expressing HSP47 mRNA and, by implication, excess collagen. These observations support the hypothesis that complement activation on tubular epithelial cells can directly increase the pro-fibrotic process associated with tubulointerstitial damage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.