ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Neurochemical and behavioral alterations in glucocorticoid receptor-impaired transgenic mice after chronic mild stress.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 119 citations in OpenAlex.
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- Age- and sex-specific effects of stress on parvalbumin interneurons in preclinical models: Relevance to sex differences in clinical neuropsychiatric and neurodevelopmental disorders.Neuroscience and biobehavioral reviews · 2021Review
- Anhedonic- and anxiogenic-like behaviors and neurochemical alterations are abolished by a single administration of a selenium-containing compound in chronically stressed mice.Comprehensive psychoneuroendocrinology · 2021Article
- Single neonatal dexamethasone administration has long-lasting outcome on depressive-like behaviour, Bdnf, Nt-3, p75ngfr and sorting receptors (SorCS1-3) stress reactive expression.Scientific reports · 2021Article
- Association Between Stressful Life Events and Female Primary Sjogren's Syndrome and Their Role in Disease Activity: A Retrospective Case-Control Study in China.Neuropsychiatric disease and treatment · 2021Article
- Depression and coronary heart disease: 2018 position paper of the ESC working group on coronary pathophysiology and microcirculation.European heart journal · 2020Article
- The associations between anxiety/depression and plasma chromogranin A among healthy workers: Results from EHOP study.Journal of occupational health · 2020Article
- Delayed Antidepressant Efficacy and the Desensitization Hypothesis.ACS chemical neuroscience · 2019Article
- Evaluation on monoamine neurotransmitters changes in depression rats given with sertraline, meloxicam or/and caffeic acid.Genes & diseases · 2019Article
- Fetal glucocorticoid receptor (Nr3c1) deficiency alters the landscape of DNA methylation of murine placenta in a sex-dependent manner and is associated to anxiety-like behavior in adulthood.Translational psychiatry · 2019Article
- On the Developmental Timing of Stress: Delineating Sex-Specific Effects of Stress across Development on Adult Behavior.Brain sciences · 2018Review
- Response of Htr3a knockout mice to antidepressant treatment and chronic stress.British journal of pharmacology · 2017Article
- MicroRNAs 29b and 181a down-regulate the expression of the norepinephrine transporter and glucocorticoid receptors in PC12 cells.Journal of neurochemistry · 2016Article
- Input-specific contributions to valence processing in the amygdala.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Review
- HPA Axis Interactions with Behavioral Systems.Comprehensive Physiology · 2016Review
- Paroxetine ameliorates changes in hippocampal energy metabolism in chronic mild stress-exposed rats.Neuropsychiatric disease and treatment · 2015Article
- Hippocampal and behavioral dysfunctions in a mouse model of environmental stress: normalization by agomelatine.Translational psychiatry · 2014Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice (GR-i) bearing a transgene encoding a glucocorticoid receptor (GR) antisense RNA under the control of a neuron-specific neurofilament promoter were used to investigate the effects of a 4 week chronic mild stress (CMS) on the hypothalamo-pituitary-adrenocortical (HPA) axis and the serotoninergic system in a transgenic model of vulnerability to affective disorders. GR-i mice showed a decrease in both GR-specific binding (hippocampus and cerebral cortex) and GR mRNA levels [hippocampus, cerebral cortex, and dorsal raphe nucleus (DRN)] as well as a deficit in HPA axis feedback control (dexamethasone test) compared with paired wild-type (WT) mice. In the latter animals, CMS exposure caused a significant decrease in both GR mRNA levels and the density of cytosolic GR binding sites in the hippocampus, whereas, in the DRN, GR mRNA levels tended to increase. In contrast, in stressed GR-i mice, both GR mRNA levels and the density of GR binding sites were significantly increased in the hippocampus, cerebral cortex, and DRN. Electrophysiological recordings in brainstem slices and [gamma-35S]GTP-S binding measurements to assess 5-HT1A receptor functioning showed that CMS exposure produced a desensitization of DRN 5-HT1A autoreceptors in WT, but not in GR-i, mice. In addition, CMS was found to facilitate choice behavior of WT, but not GR-i, mice in a decision-making task derived from an alternation paradigm. These results demonstrate that impaired GR functioning affects normal adaptive responses of the HPA axis and 5-HT system to CMS and alters stress-related consequences on decision-making behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.