ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
A novel p75 neurotrophin receptor-related protein, NRH2, regulates nerve growth factor binding to the TrkA receptor.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 69 citations in OpenAlex.
- p75 neurotrophin receptor shapes the dynamics of adult hippocampal neurogenesis in Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Confronting the loss of trophic support.Frontiers in molecular neuroscience · 2023Article
- Mouse Nerve Growth Factor Facilitates the Growth of Interspinal Schwannoma Cells by Activating NGF Receptors.Journal of Korean Neurosurgical Society · 2019Article
- Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease.Frontiers in neuroscience · 2019Review
- Synapsins Are Downstream Players of the BDNF-Mediated Axonal Growth.Molecular neurobiology · 2017Article
- Molecular Mechanism of Switching of TrkA/p75(NTR) Signaling in Monocrotophos Induced Neurotoxicity.Scientific reports · 2015Article
- Detection of p75NTR Trimers: Implications for Receptor Stoichiometry and Activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Heterodimerization of p45-p75 modulates p75 signaling: structural basis and mechanism of action.PLoS biology · 2014Article
- Interleukin-1β enhances neuronal vulnerability to proNGF-mediated apoptosis by increasing surface expression of p75(NTR) and sortillin.Neuroscience · 2014Article
- P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury.PloS one · 2013Article
- Neurotrophins in healthy and diseased skin.Dermato-endocrinology · 2011Article
- Understanding proneurotrophin actions: Recent advances and challenges.Developmental neurobiology · 2010Review
- NRH2 is a trafficking switch to regulate sortilin localization and permit proneurotrophin-induced cell death.The EMBO journal · 2009Article
- LIM kinase 1 and cofilin regulate actin filament population required for dynamin-dependent apical carrier fission from the trans-Golgi network.Molecular biology of the cell · 2009Article
- Maternal hypothyroxinemia impairs spatial learning and synaptic nature and function in the offspring.Endocrinology · 2008Article
- Neurotrophin-regulated signalling pathways.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Review
- Pro-NGF from Alzheimer's disease and normal human brain displays distinctive abilities to induce processing and nuclear translocation of intracellular domain of p75NTR and apoptosis.The American journal of pathology · 2006Article
- Critical role for Kalirin in nerve growth factor signaling through TrkA.Molecular and cellular biology · 2005Article
- Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Nerve growth factor (NGF) functions as a ligand for two receptors, the TrkA tyrosine kinase receptor and the p75 neurotrophin receptor (p75NTR). The Ig-like domains of Trk receptors and the cysteine-rich repeats of p75NTR are involved in binding to the neurotrophins. Recently, a closely related gene to p75NTR called neurotrophin receptor homolog-2 (NRH2) was identified; however, the function of NRH2 and its relevance to neurotrophin signaling are unclear. NRH2 contains a similar transmembrane and intracellular domain as p75NTR but lacks the characteristic cysteine-rich repeats in the extracellular domain. Here we show that NRH2 is expressed in several neuronal populations that also express p75NTR and Trk receptors. NRH2 does not bind to NGF; however, coimmunoprecipitation experiments demonstrate that NRH2 is capable of interacting with TrkA receptors. Coexpression of NRH2 with TrkA receptors resulted in the formation of high-affinity binding sites for NGF. These results indicate that a transmembrane protein related to p75NTR is capable of modulating Trk receptor binding properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.