ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Changes in excitability of ascending and descending inputs to cerebellar climbing fibers during locomotion.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- A disynaptic basal ganglia connection to the inferior olive: potential for basal ganglia influence on cerebellar learning.Frontiers in systems neuroscience · 2023Article
- Input and output organization of the mesodiencephalic junction for cerebro-cerebellar communication.Journal of neuroscience research · 2022Article
- Transmission of Predictable Sensory Signals to the Cerebellum via Climbing Fiber Pathways Is Gated during Exploratory Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Climbing fibers encode a temporal-difference prediction error during cerebellar learning in mice.Nature neuroscience · 2015Article
- The Periaqueductal Gray Orchestrates Sensory and Motor Circuits at Multiple Levels of the Neuraxis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Collateralization of cerebellar output to functionally distinct brainstem areas. A retrograde, non-fluorescent tracing study in the rat.Frontiers in systems neuroscience · 2014Article
- Organization of cerebral projections to identified cerebellar zones in the posterior cerebellum of the rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Article
- Stimulation within the cuneate nucleus suppresses synaptic activation of climbing fibers.Frontiers in neural circuits · 2012Article
- Electrophysiological localization of eyeblink-related microzones in rabbit cerebellar cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Cerebellar cortical activity in the cat anterior lobe during hindlimb stepping.Experimental brain research · 2008Article
- State-dependent modification of complex spike waveforms in the cerebellar cortex.Cerebellum (London, England) · 2008Article
- A novel site of synaptic relay for climbing fibre pathways relaying signals from the motor cortex to the cerebellar cortical C1 zone.The Journal of physiology · 2006Article
- Cerebellar control of the inferior olive.Cerebellum (London, England) · 2006Review
- Pontine maps linking somatosensory and cerebellar cortices are in register with climbing fiber somatotopy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The inferior olive climbing fiber projection plays a central role in all major theories of cerebellar function. Therefore, mechanisms that control the ability of climbing fibers to forward information to the cerebellum are of considerable interest. We examined changes in transmission in cerebro-olivocerebellar pathways (COCPs) and spino-olivocerebellar pathways (SOCPs) during locomotion in awake cats (n = 4) using low-intensity electrical stimuli delivered to the contralateral cerebral peduncle or the ipsilateral superficial radial nerve to set up volleys in COCPs and SOCPs, respectively. The responses were recorded as evoked extracellular climbing fiber field potentials within the C1 or C3 zones in the paravermal cerebellar cortex (lobule Va-Vc). At most C1 and C3 zone sites, the largest COCP responses occurred during the stance phase, and the smallest responses occurred during the swing phase of the ipsilateral forelimb step cycle. In marked contrast, SOCP responses recorded at the same sites were usually largest during the swing phase and smallest during the stance phase. Because substantial climbing fiber responses could be evoked in all phases of the step cycle, the results imply that olivary neurons remain excitable throughout, and that the differences between SOCPs and COCPs in their pattern of step-related modulation are unlikely to have arisen solely through inhibition at the level of the inferior olive (e.g., by activity in the inhibitory cerebellar nucleo-olivary pathway). The different patterns of modulation also suggest that climbing fiber signals conveyed by COCPs and SOCPs are likely to affect information processing within the cerebellar cortical C1 and C3 zones at different times during locomotion.
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