ArticleProceedings of the National Academy of Sciences of the United States of America2004
Coordinate enhancers share common organizational features in the Drosophila genome.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed.
- Prediction and analysis of cis-regulatory elements in Dorsal and Ventral patterning genes of Tribolium castaneum and its comparison with Drosophila melanogaster.Molecular and cellular biochemistry · 2024Article
- Article
- MAPK-mediated transcription factor GATAd contributes to Cry1Ac resistance in diamondback moth by reducing PxmALP expression.PLoS genetics · 2022Article
- Identification of new Anopheles gambiae transcriptional enhancers using a cross-species prediction approach.Insect molecular biology · 2021Article
- Annotating the Insect Regulatory Genome.Insects · 2021Review
- Enhancer grammar in development, evolution, and disease: dependencies and interplay.Developmental cell · 2021Review
- Base-resolution models of transcription-factor binding reveal soft motif syntax.Nature genetics · 2021Article
- Learning and interpreting the gene regulatory grammar in a deep learning framework.PLoS computational biology · 2020Article
- Stepwise Progression of Embryonic Patterning.Trends in genetics : TIG · 2016Review
- How to tune an enhancer.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
- Cis-regulatory architecture of a brain signaling center predates the origin of chordates.Nature genetics · 2016Article
- Quantitatively predictable control of Drosophila transcriptional enhancers in vivo with engineered transcription factors.Nature genetics · 2016Article
- Phylum-Level Conservation of Regulatory Information in Nematodes despite Extensive Non-coding Sequence Divergence.PLoS genetics · 2015Article
- The evolutionary origination and diversification of a dimorphic gene regulatory network through parallel innovations in cis and trans.PLoS genetics · 2015Article
- Su(H)-mediated repression positions gene boundaries along the dorsal-ventral axis of Drosophila embryos.Developmental cell · 2014Article
- Absence of a simple code: how transcription factors read the genome.Trends in biochemical sciences · 2014Review
- Evidence for deep regulatory similarities in early developmental programs across highly diverged insects.Genome biology and evolution · 2014Article
- Enhancer diversity and the control of a simple pattern of Drosophila CNS midline cell expression.Developmental biology · 2014Article
- Genome-scale functional characterization of Drosophila developmental enhancers in vivo.Nature · 2014Article
10 more citing papers are in PubMed but not listed here.
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2 authors.
Funding
Abstract
The evolution of animal diversity depends on changes in the regulation of a relatively fixed set of protein-coding genes. To understand how these changes might arise, we examined the organization of shared sequence motifs in four coordinately regulated neurogenic enhancers that direct similar patterns of gene expression in the early Drosophila embryo. All four enhancers possess similar arrangements of a subset of putative regulatory elements. These shared features were used to identify a neurogenic enhancer in the distantly related Anopheles genome. We suggest that the constrained organization of metazoan enhancers may be essential for their ability to produce precise patterns of gene expression during development. Organized binding sites should facilitate the identification of regulatory codes that link primary DNA sequence information with predicted patterns of gene activity.
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