ArticleJournal of neurology, neurosurgery, and psychiatry2004
Hippocampal size and memory function in the ninth and tenth decades of life: the Sydney Older Persons Study.
Article in Journal of neurology, neurosurgery, and psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Predicting categorical and continuous Alzheimer's disease outcomes from a single MRI scan.Nature aging · 2026Article
- Hippocampal microstructure, but not macrostructure, mediates age differences in episodic memory.Frontiers in aging neuroscience · 2023Article
- Maternal separation in mice leads to anxiety-like/aggressive behavior and increases immunoreactivity for glutamic acid decarboxylase and parvalbumin in the adolescence ventral hippocampus.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023Article
- Revealing the Influences of Sex Hormones and Sex Differences in Atrial Fibrillation and Vascular Cognitive Impairment.International journal of molecular sciences · 2021Review
- Task specificity impacts dual-task interference in older adults.Aging clinical and experimental research · 2021Article
- Genetic Interaction ofAging and disease · 2019Article
- Female mice with apolipoprotein E4 domain interaction demonstrated impairments in spatial learning and memory performance and disruption of hippocampal cyto-architecture.Neurobiology of learning and memory · 2019Article
- Neuroprotective and cognitive-enhancing effects of the combined extract of Cyperus rotundus and Zingiber officinale.BMC complementary and alternative medicine · 2017Article
- Medial temporal lobe contributions to intra-item associative recognition memory in the aging brain.Frontiers in behavioral neuroscience · 2013Article
- Promising therapeutics with natural bioactive compounds for improving learning and memory--a review of randomized trials.Molecules (Basel, Switzerland) · 2012Review
- Prevalence, laterality, and comorbidity of hippocampal sclerosis in an autopsy sample.Brain and behavior · 2012Article
- Female early adult depression results in detrimental impacts on the behavioral performance and brain development in offspring.CNS neuroscience & therapeutics · 2012Article
- A review of the brain structure correlates of successful cognitive aging.The Journal of neuropsychiatry and clinical neurosciences · 2011Review
- Hippocampal volumes are important predictors for memory function in elderly women.BMC medical imaging · 2009Article
- Maximum (prior) brain size, not atrophy, correlates with cognition in community-dwelling older people: a cross-sectional neuroimaging study.BMC geriatrics · 2009Article
- Asymmetric insular function predicts positional blood pressure in nondemented elderly.The Journal of neuropsychiatry and clinical neurosciences · 2009Article
- Neuroanatomical and cognitive mediators of age-related differences in episodic memory.Neuropsychology · 2008Article
- Longitudinal MRI and cognitive change in healthy elderly.Neuropsychology · 2007Article
- Differential cross-sectional and longitudinal impact of APOE genotype on hippocampal volumes in nondemented older adults.Dementia and geriatric cognitive disorders · 2007Article
- Predicting memory performance in normal ageing using different measures of hippocampal size.Neuroradiology · 2006Article
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of this study was to define magnetic resonance imaging (MRI) correlates of normal brain ageing, with the specific objective of investigating whether the size of the hippocampus is selectively correlated with age related memory performance in non-demented individuals in their ninth and tenth decades of life.
methodsHippocampal size was estimated using MRI based volumetry and qualitative visual assessment in 102 community dwelling individuals aged between 81 and 94 years. Participants were evaluated on a variety of clinical and experimental instruments, including a comprehensive neuropsychological test battery. All participants underwent neurological examination, an extensive medical history was obtained, and an informant confirmed details of each participant's functional ability.
resultsBoth visual and volumetric hippocampal measures were identified as robust predictors of memory performance, even when the influence of age related illnesses and sociodemographic variables was accounted for. When the sample was reduced to include the most cognitively healthy participants who were rated by an informant as showing no evidence of cognitive decline, the left hippocampal measures remained significant predictors of delayed retention of verbal material.
conclusionsThese findings suggest that hippocampal volumes are selectively correlated with memory functioning in both normal and successful ageing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.