Evidence map›Paper›PMID 15024658›Full record

ReviewPflugers Archiv : European journal of physiology2004

Nitrosative stress and potassium channel-mediated neuronal apoptosis: is zinc the link?

Sumon Pal, Kai He, Elias Aizenman

Open access · greenAbstract readReview
In one paragraph

Review in Pflugers Archiv : European journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Zinc in the Brain: Friend or Foe?International journal of molecular sciences · 2020
    Review
  3. Review
  4. Article
  5. Article
  6. The neurophysiology and pathology of brain zinc.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011
    Review
  7. Zinc homeostasis and signaling in health and diseases: Zinc signaling.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2011
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Reduced Ca2+ entry and suicidal death of erythrocytes in PDK1 hypomorphic mice.Pflugers Archiv : European journal of physiology · 2008
    Article
  13. Article
  14. Zinc and the liver: an active interaction.Digestive diseases and sciences · 2007
    Review
  15. Apoptotic surge of potassium currents is mediated by p38 phosphorylation of Kv2.1.Proceedings of the National Academy of Sciences of the United States of America · 2007
    Article
  16. Article
  17. Apoptotic surface delivery of K+ channels.Cell death and differentiation · 2006
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sumon PalDepartment of Neurobiology, University of Pittsburgh School of Medicine, E1456 BST, Pittsburgh, PA 15261, USA.
Kai He
Elias Aizenman
University of Pittsburgh · US

Funding

Liberation of Intracellular Zinc and Neuronal Cell DeathR01NS043277 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AIZENMAN, ELIAS · 2002 to 2022
$8.2M
Liberation of Intracellular Zinc and Neuronal Cell DeathR56NS043277 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AIZENMAN, ELIAS · 2007 to 2007
$371k
NINDS NIH HHS NS43277NINDS NIH HHS R01 NS043277NINDS NIH HHS R56 NS043277
6 · The paper itself

Abstract

Nitrosative stress has been implicated in a large number of neurological disorders. The molecular mechanisms underlying the neuronal injury associated with this stimulus, however, are not clearly understood. Emerging evidence suggests that the liberation of intracellular zinc as well as over-activation of potassium channels may be two important components of nitrosative stress-induced neuronal death.

Indexed as

AnimalsApoptosisHumansNeuronsOxidative StressPeroxynitrous AcidPotassium Channels, Voltage-GatedTyrosineZinc3-nitrotyrosinePeroxynitrous AcidPotassium Channels, Voltage-GatedTyrosineZinc

Identifiers

PMID15024658
PMCPMC2945503
OpenAlexW2080934825

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.