ArticlePLoS biology2004
No evidence of Neandertal mtDNA contribution to early modern humans.
Article in PLoS biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 1 of them a synthesis that pooled it.
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Who cites it
87 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Strategies to work with HLA data in human populations for histocompatibility, clinical transplantation, epidemiology and population genetics: HLA-NET methodological recommendations.International journal of immunogenetics · 2012Guideline
- Recent advances in methods to characterize archaic introgression in modern humans.Genome research · 2026Review
- G-quadruplex propensity inNAR genomics and bioinformatics · 2024Article
- Convergent Mutations and Single Nucleotide Variants in Mitochondrial Genomes of Modern Humans and Neanderthals.International journal of molecular sciences · 2024Article
- Advancements and Challenges in Ancient DNA Research: Bridging the Global North-South Divide.Genes · 2023Review
- Resolving the "muddle in the middle": The case for Homo bodoensis sp. nov.Evolutionary anthropology · 2022Article
- Inferring archaic introgression from hominin genetic data.Evolutionary anthropology · 2021Review
- Reevaluating the timing of Neanderthal disappearance in Northwest Europe.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A mitochondrial genetic divergence proxy predicts the reproductive compatibility of mammalian hybrids.Proceedings. Biological sciences · 2020Article
- Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.Cell · 2019Article
- Investigating mitonuclear interactions in human admixed populations.Nature ecology & evolution · 2019Article
- High-throughput inference of pairwise coalescence times identifies signals of selection and enriched disease heritability.Nature genetics · 2018Article
- AntCaller: an accurate variant caller incorporating ancient DNA damage.Molecular genetics and genomics : MGG · 2017Article
- The Mitonuclear Dimension of Neanderthal and Denisovan Ancestry in Modern Human Genomes.Genome biology and evolution · 2017Article
- Article
- Human evolution: a tale from ancient genomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Resurrecting the Dead (Molecules).Computational and structural biotechnology journal · 2017Review
- IBD Sharing between Africans, Neandertals, and Denisovans.Genome biology and evolution · 2016Article
- The Strength of Selection against Neanderthal Introgression.PLoS genetics · 2016Article
- Detecting hybridization using ancient DNA.Molecular ecology · 2016Review
27 more citing papers are in PubMed but not listed here.
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The retrieval of mitochondrial DNA (mtDNA) sequences from four Neandertal fossils from Germany, Russia, and Croatia has demonstrated that these individuals carried closely related mtDNAs that are not found among current humans. However, these results do not definitively resolve the question of a possible Neandertal contribution to the gene pool of modern humans since such a contribution might have been erased by genetic drift or by the continuous influx of modern human DNA into the Neandertal gene pool. A further concern is that if some Neandertals carried mtDNA sequences similar to contemporaneous humans, such sequences may be erroneously regarded as modern contaminations when retrieved from fossils. Here we address these issues by the analysis of 24 Neandertal and 40 early modern human remains. The biomolecular preservation of four Neandertals and of five early modern humans was good enough to suggest the preservation of DNA. All four Neandertals yielded mtDNA sequences similar to those previously determined from Neandertal individuals, whereas none of the five early modern humans contained such mtDNA sequences. In combination with current mtDNA data, this excludes any large genetic contribution by Neandertals to early modern humans, but does not rule out the possibility of a smaller contribution.
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