ArticleProceedings of the National Academy of Sciences of the United States of America2004
Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 116 citations in OpenAlex.
- Long-term facilitation of ventilation following acute continuous hypoxia in awake humans during sustained hypercapnia.The Journal of physiology · 2012Trial
- Identification of multiple hypoxia-independent triggers of upper airway long-term facilitation in a rat model of upper airway motor plasticity.Physiological reports · 2025Article
- Review
- Daily acute intermittent hypoxia enhances serotonergic innervation of hypoglossal motor nuclei in rats with and without cervical spinal injury.Experimental neurology · 2022Article
- Central respiratory chemoreception.Handbook of clinical neurology · 2022Review
- Adenosine A2a receptors modulate TrkB receptor-dependent respiratory plasticity in neonatal rats.Respiratory physiology & neurobiology · 2021Article
- Daily acute intermittent hypoxia enhances phrenic motor output and stimulus-evoked phrenic responses in rats.Journal of neurophysiology · 2021Article
- How Are Adenosine and Adenosine ABiomedicines · 2021Review
- Electrical epidural stimulation of the cervical spinal cord: implications for spinal respiratory neuroplasticity after spinal cord injury.Journal of neurophysiology · 2021Review
- Synergy between Acute Intermittent Hypoxia and Task-Specific Training.Exercise and sport sciences reviews · 2020Review
- Impact of inflammation on developing respiratory control networks: rhythm generation, chemoreception and plasticity.Respiratory physiology & neurobiology · 2020Review
- Intermittent but not sustained moderate hypoxia elicits long-term facilitation of hypoglossal motor output.Respiratory physiology & neurobiology · 2018Article
- The impact of inflammation on respiratory plasticity.Experimental neurology · 2017Review
- Reduced respiratory neural activity elicits a long-lasting decrease in the COExperimental neurology · 2017Article
- Generation of active expiration by serotoninergic mechanisms of the ventral medulla of rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Long-term facilitation of expiratory and sympathetic activities following acute intermittent hypoxia in rats.Acta physiologica (Oxford, England) · 2016Article
- Power spectral analysis of hypoglossal nerve activity during intermittent hypoxia-induced long-term facilitation in mice.Journal of neurophysiology · 2016Article
- Effect of Systemic Application of 5-Hydroxytryptamine on Hypoglossal Nerve Discharge in Anesthetized Rats.Journal of molecular neuroscience : MN · 2015Article
- Serotonin neurons and central respiratory chemoreception: where are we now?Progress in brain research · 2014Review
- Spinal TNF is necessary for inactivity-induced phrenic motor facilitation.The Journal of physiology · 2013Article
9 more citing papers are in PubMed but not listed here.
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2 authors at 1 institution in 1 country.
Funding
Abstract
Potentiation and depression of glutamate receptor function in hippocampal, cerebellar, and cortical neurons are examples of persistent changes in synaptic function that underlie important behavioral adaptations such as learning and memory. Persistent changes in synaptic function relevant for motor behaviors have not been demonstrated in mammalian motoneurons. We demonstrate that adaptive changes in (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid hydrobromide (AMPA) receptor function at endogenously active synapses occur in motoneurons in neonatal rodents. We found a form of serotonin (5-HT)-dependent synaptic plasticity in hypoglossal (XII) motoneurons, which control tongue muscles affecting upper airway function, that is metamodulated by metabotropic glutamate receptors. Episodic, but not continuous, activation of postsynaptic 5-HT type 2 (5-HT(2)) receptors on hypoglossal (XII) motoneurons leads to long-lasting increases in their AMPA receptor-mediated respiratory drive currents and associated XII nerve motor output. Antagonism of group-I metabotropic glutamate receptors blocks induction of the 5-HT-induced increase in excitability. We propose that this activity-independent postsynaptic 5-HT-mediated plasticity represents the cellular mechanism underlying long-term facilitation, i.e., persistent increases in respiratory motor output and ventilation seen in humans and rodents in response to episodic hypoxia. Loss of activity in XII motoneurons is common during sleep causing snoring and, in serious cases, airway obstruction that interrupts breathing, a condition known as obstructive sleep apnea. These results may provide the basis for rationale development of therapeutics for obstructive sleep apnea in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.