ArticleMolecular and cellular biology2004
A nonconserved surface of the TFIIB zinc ribbon domain plays a direct role in RNA polymerase II recruitment.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Emerging roles of POLR2L of RNA polymerase II dynamics and disease mechanisms (Review).Molecular medicine reports · 2026Review
- The bacterial enhancer-dependent RNA polymerase.The Biochemical journal · 2016Review
- Downregulation of NIN/RPN12 binding protein inhibit the growth of human hepatocellular carcinoma cells.Molecular biology reports · 2012Article
- Plant MCM proteins: role in DNA replication and beyond.Plant molecular biology · 2011Review
- Minimal promoter systems reveal the importance of conserved residues in the B-finger of human transcription factor IIB.The Journal of biological chemistry · 2009Article
- The plant-specific TFIIB-related protein, pBrp, is a general transcription factor for RNA polymerase I.The EMBO journal · 2008Article
- Control of the timing of promoter escape and RNA catalysis by the transcription factor IIb fingertip.The Journal of biological chemistry · 2008Article
- Structural analysis of the Sulfolobus solfataricus MCM protein N-terminal domain.Nucleic acids research · 2008Article
- The central cell plays a critical role in pollen tube guidance in Arabidopsis.The Plant cell · 2007Article
- TFIIB and the regulation of transcription by RNA polymerase II.Chromosoma · 2007Review
- Assembly of transcription factor IIB at a promoter in vivo requires contact with RNA polymerase II.EMBO reports · 2006Article
- Structure-function analysis of the human TFIIB-related factor II protein reveals an essential role for the C-terminal domain in RNA polymerase III transcription.Molecular and cellular biology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The general transcription factor TFIIB is a highly conserved and essential component of the eukaryotic RNA polymerase II (pol II) transcription initiation machinery. It consists of a single polypeptide with two conserved structural domains: an amino-terminal zinc ribbon structure (TFIIB(ZR)) and a carboxy-terminal core (TFIIB(CORE)). We have analyzed the role of the amino-terminal region of human TFIIB in transcription in vivo and in vitro. We identified a small nonconserved surface of the TFIIB(ZR) that is required for pol II transcription in vivo and for different types of basal pol II transcription in vitro. Consistent with a general role in transcription, this TFIIB(ZR) surface is directly involved in the recruitment of pol II to a TATA box-containing promoter. Curiously, although the amino-terminal human TFIIB(ZR) domain can recruit both human pol II and yeast (Saccharomyces cerevisiae) pol II, the yeast TFIIB amino-terminal region recruits yeast pol II but not human pol II. Thus, a critical process in transcription from many different promoters-pol II recruitment-has changed in sequence specificity during eukaryotic evolution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.