ArticleMolecular and cellular biology2004
Securin is a target of the UV response pathway in mammalian cells.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
- SCF(FBXW7)-mediated degradation of p53 promotes cell recovery after UV-induced DNA damage.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Both p62/SQSTM1-HDAC6-dependent autophagy and the aggresome pathway mediate CDK1 degradation in human breast cancer.Scientific reports · 2017Article
- βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy.Oncotarget · 2014Article
- SCF(FBXW7α) modulates the intra-S-phase DNA-damage checkpoint by regulating Polo like kinase-1 stability.Oncotarget · 2014Article
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- Glycogen synthase kinase-3beta (GSK3beta) negatively regulates PTTG1/human securin protein stability, and GSK3beta inactivation correlates with securin accumulation in breast tumors.The Journal of biological chemistry · 2011Article
- Expression profile of DNA damage signaling genes in 2 Gy proton exposed mouse brain.Molecular and cellular biochemistry · 2010Article
- Cohesin promotes the repair of ionizing radiation-induced DNA double-strand breaks in replicated chromatin.Nucleic acids research · 2010Article
- Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines.Cell proliferation · 2008Article
- The ubiquitin ligase APC(Cdh1) is required to maintain genome integrity in primary human cells.Oncogene · 2008Article
- Naturally occurring and stress induced tubular structures from mammalian cells, a survival mechanism.BMC cell biology · 2007Article
- Identification of a nuclear-localized nuclease from wheat cells undergoing programmed cell death that is able to trigger DNA fragmentation and apoptotic morphology on nuclei from human cells.The Biochemical journal · 2006Article
- Protein phosphatase 2A stabilizes human securin, whose phosphorylated forms are degraded via the SCF ubiquitin ligase.Molecular and cellular biology · 2006Article
- Pituitary tumour transforming gene (PTTG) induces genetic instability in thyroid cells.Oncogene · 2005Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All eukaryotic cells possess elaborate mechanisms to protect genome integrity and ensure survival after DNA damage, ceasing proliferation and granting time for DNA repair. Securin is an inhibitory protein that is bound to a protease called Separase to inhibit sister chromatid separation until the onset of anaphase. At the metaphase-to-anaphase transition, Securin is degraded by the anaphase-promoting complex or cyclosome, and Separase contributes to the release of cohesins from the chromosome, allowing for the segregation of sister chromatids to opposite spindle poles. Here we provide evidence that human Securin (hSecurin) has a novel role in cell cycle arrest after exposure to UV light or ionizing radiation. In fact, irradiation downregulated the level of hSecurin protein, accelerating its degradation via the proteasome and reducing hSecurin mRNA translation, but the presence of hSecurin is necessary for cell proliferation arrest following UV treatment. Moreover, an alteration of UV-induced hSecurin downregulation could lead directly to the accumulation of DNA damage and the subsequent development of malignant tumors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.