ArticleCurrent genetics2004
A new enrichment approach identifies genes that alter cell cycle progression in Saccharomyces cerevisiae.
Article in Current genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Thermoplastic microfluidic bioreactors with integrated electrodes to study tumor treating fields on yeast cells.Biomicrofluidics · 2020Article
- Yeast genetic interaction screens in the age of CRISPR/Cas.Current genetics · 2019Review
- Translational control of lipogenic enzymes in the cell cycle of synchronous, growing yeast cells.The EMBO journal · 2017Article
- Article
- Improved functional overview of protein complexes using inferred epistatic relationships.BMC systems biology · 2011Article
- The Dcr2p phosphatase destabilizes Sic1p in Saccharomyces cerevisiae.Biochemical and biophysical research communications · 2007Article
- Yeast Rrp14p is required for ribosomal subunit synthesis and for correct positioning of the mitotic spindle during mitosis.Nucleic acids research · 2007Article
- A role for KEM1 at the START of the cell cycle in Saccharomyces cerevisiae.Current genetics · 2005Article
- Gid8p (Dcr1p) and Dcr2p function in a common pathway to promote START completion in Saccharomyces cerevisiae.Eukaryotic cell · 2004Article
- Hym1p affects cell cycle progression in Saccharomyces cerevisiae.Current genetics · 2004Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Mechanisms that coordinate cell growth with division are thought to determine the timing of initiation of cell division and to limit overall cell proliferation. To identify genes involved in this process in Saccharomyces cerevisiae, we describe a method that does not rely on cell size alterations or resistance to pheromone. Instead, our approach was based on the cell surface deposition of the Flo1p protein in cells having passed START. We found that over-expression of HXT11 (which encodes a plasma membrane transporter), PPE1 (coding for a protein methyl esterase), or SIK1 (which encodes a protein involved in rRNA processing) shortened the duration of the G1 phase of the cell cycle, prior to the initiation of DNA replication. In addition, we found that, although SIK1 was not part of a mitotic checkpoint, SIK1 over-expression caused spindle orientation defects and sensitized G2/M checkpoint mutant cells. Thus, unlike HXT11 and PPE1, SIK1 over-expression is also associated with mitotic functions. Overall, we used a novel enrichment approach and identified genes that were not previously associated with cell cycle progression. This approach can be extended to other organisms.
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Registered trials
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