ArticleOncogene2004
Multiple cell-type-specific elements regulate Myc protein stability.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- c-Myc: an emerging participant in heart failure.Frontiers in cardiovascular medicine · 2026Review
- Review
- When Just One Phosphate Is One Too Many: The Multifaceted Interplay between Myc and Kinases.International journal of molecular sciences · 2023Review
- Co-Operativity between MYC and BCL-2 Pro-Survival Proteins in Cancer.International journal of molecular sciences · 2021Review
- A modular degron library for synthetic circuits in mammalian cells.Nature communications · 2019Article
- Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis.Journal of experimental & clinical cancer research : CR · 2018Review
- Review
- Article
- Therapeutic strategies to inhibit MYC.Cold Spring Harbor perspectives in medicine · 2014Review
- MYC degradation.Cold Spring Harbor perspectives in medicine · 2014Review
- An overview of MYC and its interactome.Cold Spring Harbor perspectives in medicine · 2014Review
- STK38 is a critical upstream regulator of MYC's oncogenic activity in human B-cell lymphoma.Oncogene · 2013Article
- Article
- Proline-mediated proteasomal degradation of the prostate-specific tumor suppressor NKX3.1.The Journal of biological chemistry · 2012Article
- WWP1: a versatile ubiquitin E3 ligase in signaling and diseases.Cellular and molecular life sciences : CMLS · 2012Review
- Myc proteins as therapeutic targets.Oncogene · 2010Article
- PML4 induces differentiation by Myc destabilization.Oncogene · 2007Article
- Constitutive turnover of cyclin E by Cul3 maintains quiescence.Molecular and cellular biology · 2007Article
- Degrons at the C terminus of the pathogenic but not the nonpathogenic hantavirus G1 tail direct proteasomal degradation.Journal of virology · 2007Article
- A conserved pathway that controls c-Myc protein stability through opposing phosphorylation events occurs in yeast.The Journal of biological chemistry · 2007Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Myc is a highly unstable transcription factor that is destroyed by ubiquitin (Ub)-mediated proteolysis. We have previously identified an amino-terminal 'degron' within Myc that signals its destruction; this degron spans the transcriptional activation domain of Myc, and includes two highly conserved regions called Myc boxes I and II. We now report the identification of a second element--the D-element--which is also required for Myc proteolysis. The centrally located D-element is distinct from the PEST domain in Myc, but includes Myc box III, a third highly conserved region with no previously known function. We show that deletion of the D-element stabilizes the Myc protein without affecting its ubiquitylation, and report that the D-element and the degron act in a cell-type-specific manner to direct Myc proteolysis. These data thus demonstrate that Myc stability is regulated at both the ubiquitylation and postubiquitylation levels, and reveal that substrates of the Ub-proteasome system can be targeted for destruction differently in different cell types.
Indexed as
Identifiers
15021906What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.