ArticleProceedings of the National Academy of Sciences of the United States of America1992
The T-DNA-linked VirD2 protein contains two distinct functional nuclear localization signals.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed.
- A comprehensive in silico genome-wide identification and characterization of SQUAMOSA promoter binding protein (SBP) gene family in Musa acuminata.Journal, genetic engineering & biotechnology · 2025Article
- Genomic consequences associated with Agrobacterium-mediated transformation of plants.The Plant journal : for cell and molecular biology · 2024Review
- Discovery of a Novel Member of thePathogens (Basel, Switzerland) · 2021Article
- JAZ8 Interacts With VirE3 Attenuating Agrobacterium Mediated Root Tumorigenesis.Frontiers in plant science · 2021Article
- Bacterial nucleomodulins: A coevolutionary adaptation to the eukaryotic command center.PLoS pathogens · 2021Review
- Article
- Strength in Diversity: Nuclear Export of Viral RNAs.Viruses · 2020Review
- Evolutionary gradient of predicted nuclear localization signals (NLS)-bearing proteins in genomes of family Planctomycetaceae.BMC microbiology · 2017Article
- The roles of bacterial and host plant factors in Agrobacterium-mediated genetic transformation.The International journal of developmental biology · 2013Review
- Poinsettia protoplasts - a simple, robust and efficient system for transient gene expression studies.Plant methods · 2012Article
- Bacterial effectors target the plant cell nucleus to subvert host transcription.Plant signaling & behavior · 2012Review
- Traversing the Cell: Agrobacterium T-DNA's Journey to the Host Genome.Frontiers in plant science · 2012Article
- Conjugative DNA transfer into human cells by the VirB/VirD4 type IV secretion system of the bacterial pathogen Bartonella henselae.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- A plethora of virulence strategies hidden behind nuclear targeting of microbial effectors.Frontiers in plant science · 2011Article
- Agrobacterium tumefaciens and A. rhizogenes use different proteins to transport bacterial DNA into the plant cell nucleus.Microbial biotechnology · 2009Review
- The Agrobacterium rhizogenes GALLS gene encodes two secreted proteins required for genetic transformation of plants.Journal of bacteriology · 2009Article
- IMPa-4, an Arabidopsis importin alpha isoform, is preferentially involved in agrobacterium-mediated plant transformation.The Plant cell · 2008Article
- Terminal proteins of Streptomyces chromosome can target DNA into eukaryotic nuclei.Nucleic acids research · 2008Article
- Predicting the nuclear localization signals of 107 types of HPV L1 proteins by bioinformatic analysis.Genomics, proteomics & bioinformatics · 2006Article
- Sea urchin vault structure, composition, and differential localization during development.BMC developmental biology · 2005Article
5 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
Agrobacterium tumefaciens causes neoplastic growth in plants by transferring a piece of DNA, called T-DNA, into the nucleus of the plant cell. The virulence protein VirD2 of A. tumefaciens is tightly linked to the T-DNA and is thought to direct it to the plant genome. Here we show that the VirD2 protein contains two nuclear localization signals that are functional both in yeast and in plant cells. One signal is located in the N-terminal part of the protein and resembles a single-cluster-type nuclear localization signal. The second signal is near the C terminus and is a bipartite-type nuclear localization signal. The involvement of these sequences in the entry of the T-DNA into the nucleus is discussed.
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