ArticleClinical orthopaedics and related research2004
Myofibroblast numbers are elevated in human elbow capsules after trauma.
Article in Clinical orthopaedics and related research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 107 citations in OpenAlex.
- Gene expression and histological assessment of capsular fibrosis in post-traumatic shoulder stiffness following plate fixation of proximal humeral fractures: an exploratory pilot study.BMC musculoskeletal disorders · 2026Article
- Impact of immobilization period and anterior capsular injury on flexion contracture in distal humerus coronal shear fractures.Clinics in shoulder and elbow · 2025Article
- Capsule release surgery temporarily reduces contracture in a rat elbow model of arthrofibrosis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Age-related changes in rat joint capsule.Journal of physical therapy science · 2023Article
- Pleiotropic Long-Term Effects of Atorvastatin on Posttraumatic Joint Contracture in a Rat Model.Pharmaceutics · 2022Article
- THE POLYMORPHISM OF METALLOPROTEINASES 1 AND 13 AND POSTTRAUMATIC ELBOW STIFFNESS.Acta ortopedica brasileira · 2022Article
- Preclinical Models of Elbow Injury and Pathology.Annals of joint · 2021Article
- Lumican promotes joint fibrosis through TGF-β signaling.FEBS open bio · 2020Article
- CD34 positive cells isolated from traumatized human skeletal muscle require the CD34 protein for multi-potential differentiation.Cellular signalling · 2020Article
- Receptor tyrosine kinase ligands and inflammatory cytokines cooperatively suppress the fibrogenic activity in temporomandibular-joint-derived fibroblast-like synoviocytes via mitogen-activated protein kinase kinase/extracellular signal-regulated kinase.Experimental and therapeutic medicine · 2020Article
- Multiple rare causes of post-traumatic elbow stiffness in an adolescent patient: A case report and review of literature.World journal of clinical cases · 2019Review
- Effects of losartan and atorvastatin on the development of early posttraumatic joint stiffness in a rat model.Drug design, development and therapy · 2019Article
- Temporal Patterns of Motion in Flexion-extension and Pronation-supination in a Rat Model of Posttraumatic Elbow Contracture.Clinical orthopaedics and related research · 2018Article
- Arthroscopic debridement for primary elbow osteoarthritis with and without capsulectomy: a comparative cohort study.Shoulder & elbow · 2018Article
- Intra-articular implantation of collagen scaffold carriers is safe in both native and arthrofibrotic rabbit knee joints.Bone & joint research · 2017Article
- The posttraumatic stiff elbow: an update.Current reviews in musculoskeletal medicine · 2016Review
- Effect of pERK2 on extracellular matrix turnover of the fibrotic joint capsule in a post-traumatic joint contracture model.Experimental and therapeutic medicine · 2016Article
- Inhibition of Contractile Function in Human Joint Capsule Myofibroblasts by Targeting the TGF-β1 and PDGF Pathways.PloS one · 2016Article
- Neuroinflammatory Mechanisms of Connective Tissue Fibrosis: Targeting Neurogenic and Mast Cell Contributions.Advances in wound care · 2015Review
- The use of dynamic orthoses in the treatment of the stiff elbow.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Elbow contractures, a frequent problem after injury, can be treated by excision of the joint capsule. However, the underlying changes in the joint capsule are poorly understood. Based on skin healing work, we examined the hypotheses that myofibroblast numbers and expression of a myofibroblast marker alpha-smooth muscle actin, are elevated in patients with posttraumatic joint contractures. Anterior capsules were obtained from six patients who had operative release of posttraumatic contractures greater than 5 months after injury and six elbows of organ donors free of contractures. Immunohistochemical studies revealed that myofibroblast numbers and percentage of total cells that were myofibroblasts were significantly elevated in the joint capsules from patients with contractures (326 +/- 61 cells per field, 36% +/- 4% total cells) when compared with similar tissues of the organ donors (69 +/- 41 cells per field, 9% +/- 4% total cells). Western blot analysis showed that protein levels of alpha-smooth muscle actin were significantly elevated in patients with posttraumatic joint contractures. However, analysis with reverse transcription-polymerase chain reaction determined that messenger ribonucleic acid levels for smooth muscle actin normalized to the housekeeping gene glyceraldehyde-3-phosphate dehydrogenase were not significantly different between the two groups. An association between increased numbers of myofibroblasts and posttraumatic joint contractures has been established in the human elbow capsule. Additional work is required to determine whether myofibroblast regulators may be targets for adjuvant therapies of posttraumatic contractures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.