ArticleThe Plant cell2004
Genetic interaction of an origin recognition complex subunit and the Polycomb group gene MEDEA during seed development.
Article in The Plant cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 65 citations in OpenAlex.
- Regulation of cell cycle in plant gametes: when is the right time to divide?Development (Cambridge, England) · 2025Review
- Cell cycle status of male and female gametes during Arabidopsis reproduction.Plant physiology · 2023Article
- Topological data analysis reveals a core gene expression backbone that defines form and function across flowering plants.PLoS biology · 2023Article
- Use ofHeliyon · 2023Article
- Genome-wide association study of soybean (Frontiers in plant science · 2023Article
- High Ambient Temperature Regulated the Plant Systemic Response to the Beneficial Endophytic FungusFrontiers in plant science · 2022Article
- Degradome Analysis of Tomato andInternational journal of molecular sciences · 2021Article
- ABAP1 Plays a Role in the Differentiation of Male and Female Gametes inFrontiers in plant science · 2021Article
- The Armadillo BTB Protein ABAP1 Is a Crucial Player in DNA Replication and Transcription of Nematode-Induced Galls.Frontiers in plant science · 2021Article
- The plant cell cycle: Pre-Replication complex formation and controls.Genetics and molecular biology · 2017Article
- The role of the MCM2-7 helicase complex during Arabidopsis seed development.Plant molecular biology · 2014Article
- The Arabidopsis transcription factor IIB-related protein BRP4 is involved in the regulation of mitotic cell-cycle progression during male gametogenesis.Journal of experimental botany · 2014Article
- Interactions among rice ORC subunits.Plant signaling & behavior · 2013Article
- The Armadillo repeat gene ZAK IXIK promotes Arabidopsis early embryo and endosperm development through a distinctive gametophytic maternal effect.The Plant cell · 2012Article
- Protein interaction network of Arabidopsis thaliana female gametophyte development identifies novel proteins and relations.PloS one · 2012Article
- Initiation of DNA replication: functional and evolutionary aspects.Annals of botany · 2011Review
- Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Transcriptional profiles underlying parent-of-origin effects in seeds of Arabidopsis thaliana.BMC plant biology · 2010Article
- The contribution of cell cycle regulation to endosperm development.Sexual plant reproduction · 2009Review
- Arabidopsis ORC1 is a PHD-containing H3K4me3 effector that regulates transcription.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The eukaryotic origin recognition complex (ORC) is made up of six subunits and functions in nuclear DNA replication, chromatin structure, and gene silencing in both fungi and metazoans. We demonstrate that disruption of a plant ORC subunit homolog, AtORC2 of Arabidopsis (Arabidopsis thaliana), causes a zygotic lethal mutant phenotype (orc2). Seeds of orc2 abort early, typically producing embryos with up to eight cells. Nuclear division in the endosperm is arrested at an earlier developmental stage: only approximately four nuclei are detected in orc2 endosperm. The endosperm nuclei in orc2 are dramatically enlarged, a phenotype that is most similar to class B titan mutants, which include mutants in structural maintenance of chromosomes (SMC) cohesins. The highest levels of ORC2 gene expression were found in preglobular embryos, coinciding with the stage at which homozygous orc2 mutant seeds arrest. The homologs of the other five Arabidopsis ORC subunits are also expressed at this developmental stage. The orc2 mutant phenotype is partly suppressed by a mutation in the Polycomb group gene MEDEA. In double mutants between orc2 and medea (mea), orc2 homozygotes arrest later with a phenotype intermediate between those of mea and orc2 single mutants. Either alterations in chromatin structure or the release of cell cycle checkpoints by the mea mutation may allow more cell and nuclear divisions to occur in orc2 homozygous seeds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.