ArticleThe Journal of physiology2004
Multiple mechanisms govern the dynamics of depression at neocortical synapses of young rats.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Inferring synaptic transmission from the stochastic dynamics of the quantal content: An analytical approach.PLoS computational biology · 2025Article
- Synaptic zinc potentiates AMPA receptor function in mouse auditory cortex.Cell reports · 2023Article
- Multiscale modeling of presynaptic dynamics from molecular to mesoscale.PLoS computational biology · 2022Article
- Munc13-1 is a CaNeuron · 2021Article
- Linear-nonlinear cascades capture synaptic dynamics.PLoS computational biology · 2021Article
- Article
- Estimating the Readily-Releasable Vesicle Pool Size at Synaptic Connections in the Neocortex.Frontiers in synaptic neuroscience · 2019Article
- Model-Based Inference of Synaptic Transmission.Frontiers in synaptic neuroscience · 2019Review
- Matched Short-Term Depression and Recovery Encodes Interspike Interval at a Central Synapse.Scientific reports · 2018Article
- Noradrenaline Increases mEPSC Frequency in Pyramidal Cells in Layer II of Rat Barrel Cortex via Calcium Release From Presynaptic Stores.Frontiers in cellular neuroscience · 2018Article
- Phase changes in neuronal postsynaptic spiking due to short term plasticity.PLoS computational biology · 2017Article
- Article
- Bayesian Inference of Synaptic Quantal Parameters from Correlated Vesicle Release.Frontiers in computational neuroscience · 2016Article
- Distinct recurrent versus afferent dynamics in cortical visual processing.Nature neuroscience · 2015Article
- A kinetic model for the frequency dependence of cholinergic modulation at hippocampal GABAergic synapses.Mathematical biosciences · 2014Article
- Article
- The effects of short-term synaptic depression at thalamocortical synapses on orientation tuning in cat V1.PloS one · 2014Article
- Mathematical analysis and algorithms for efficiently and accurately implementing stochastic simulations of short-term synaptic depression and facilitation.Frontiers in computational neuroscience · 2013Article
- Theoretical models of synaptic short term plasticity.Frontiers in computational neuroscience · 2013Article
- Interaction of short-term depression and firing dynamics in shaping single neuron encoding.Frontiers in computational neuroscience · 2013Article
Corrections and comments
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5 authors.
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Abstract
Synaptic transmission between pairs of excitatory neurones in layers V (N= 38) or IV (N= 6) of somatosensory cortex was examined in a parasagittal slice preparation obtained from young Wistar rats (14-18 days old). A combined experimental and theoretical approach reveals two characteristics of short-term synaptic depression. Firstly, as well as a release-dependent depression, there is a release-independent component that is evident in smaller postsynaptic responses even following failure to release transmitter. Secondly, recovery from depression is activity dependent and is faster at higher input frequencies. Frequency-dependent recovery is a Ca(2+)-dependent process and does not reflect an underlying augmentation. Frequency-dependent recovery and release-independent depression are correlated, such that at those connections with a large amount of release-independent depression, recovery from depression is faster. In addition, both are more pronounced in experiments performed at physiological temperatures. Simulations demonstrate that these homeostatic properties allow the transfer of rate information at all frequencies, essentially linearizing synaptic responses at high input frequencies.
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