ArticleGenetics2004
Meiotic recombination between paralogous RBCSB genes on sister chromatids of Arabidopsis thaliana.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Gene Body Methylation in Plants: Mechanisms, Functions, and Important Implications for Understanding Evolutionary Processes.Genome biology and evolution · 2022Review
- Chimeras Linked to Tandem Repeats and Transposable Elements in Tetraploid Hybrid Fish.Marine biotechnology (New York, N.Y.) · 2017Article
- A comparative analysis of insertional effects in genetically engineered plants: considerations for pre-market assessments.Transgenic research · 2015Review
- Pericentromeric effects shape the patterns of divergence, retention, and expression of duplicated genes in the paleopolyploid soybean.The Plant cell · 2012Article
- Conservation and purifying selection of transcribed genes located in a rice centromere.The Plant cell · 2011Article
- Natural diversity in flowering responses of Arabidopsis thaliana caused by variation in a tandem gene array.Genetics · 2010Article
- The evolution of a high copy gene array in Arabidopsis.Journal of molecular evolution · 2010Article
- The rate of unequal crossing over in the dumpy gene from Drosophila melanogaster.Journal of molecular evolution · 2010Article
- Meiosis-driven genome variation in plants.Current genomics · 2007Article
- Striking similarities in the genomic distribution of tandemly arrayed genes in Arabidopsis and rice.PLoS computational biology · 2006Article
- Unequal sister chromatid and homolog recombination at a tandem duplication of the A1 locus in maize.Genetics · 2006Article
- Frequency and character of alternative somatic recombination fates of paralogous genes during T-DNA integration.Molecular genetics and genomics : MGG · 2005Article
- Comparisons of maize pericarp color1 alleles reveal paralogous gene recombination and an organ-specific enhancer region.The Plant cell · 2005Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Paralogous genes organized as a gene cluster can rapidly evolve by recombination between misaligned paralogs during meiosis, leading to duplications, deletions, and novel chimeric genes. To model unequal recombination within a specific gene cluster, we utilized a synthetic RBCSB gene cluster to isolate recombinant chimeric genes resulting from meiotic recombination between paralogous genes on sister chromatids. Several F1 populations hemizygous for the synthRBCSB1 gene cluster gave rise to Luc+ F2 plants at frequencies ranging from 1 to 3 x 10(-6). A nonuniform distribution of recombination resolution sites resulted in the biased formation of recombinant RBCS3B/1B::LUC genes with nonchimeric exons. The positioning of approximately half of the mapped resolution sites was effectively modeled by the fractional length of identical DNA sequences. In contrast, the other mapped resolution sites fit an alternative model in which recombination resolution was stimulated by an abrupt transition from a region of relatively high sequence similarity to a region of low sequence similarity. Thus, unequal recombination between paralogous RBCSB genes on sister chromatids created an allelic series of novel chimeric genes that effectively resulted in the diversification rather than the homogenization of the synthRBCSB1 gene cluster.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.